Results 71 to 80 of about 458,996 (249)

Is It Time to Begin a Public Campaign Concerning Frailty and Pre-frailty? A Review Article

open access: yesFrontiers in Physiology, 2017
Frailty is a state that encompasses losses in physical, psychological or social domains. Therefore, frail people demonstrate a reduced potential to manage external stressors and to respond to life incidents.
Jerzy Sacha   +5 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Weak Diamond

open access: yes, 2001
Under some cardinal arithmetic assumptions, we prove that every stationary subset of lambda of a right cofinality has the weak diamond. This is a strong negation of uniformization. We then deal with a weaker version of the weak diamond- colouring restrictions. We then deal with semi- saturated (normal) filters.
openaire   +3 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Survey of changes in subjective symptoms among Japanese polio survivors over 10 years

open access: yesJournal of Rehabilitation Medicine
Objective: To define long-term changes in subjective symptoms among polio survivors in Japan. Design: Prospective cohort study. Patients: Sixty-five polio survivors.
Fumi Toda   +6 more
doaj   +1 more source

Strength in weakness: a mystery of hope [PDF]

open access: yesChristian Journal for Global Health
A vocation to serving in severely medically under-resourced settings invariably means facing of our own weakness in realizing that vocation. Christian teaching proclaims that God’s strength in made perfect in weakness, which is both a comfort and a ...
Eric McLaughlin
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

Adult Onset Acute Disseminated Encephalomyelitis (ADEM): A Comprehensive Case Repot

open access: yesSaudi Journal of Emergency Medicine
INTRODUCTION: Acute disseminated encephalomyelitis (ADEM) is a rare immune-mediated condition affecting the central nervous system, characterized by acute encephalopathy and multifocal neurological deficits.
Imad Mohammed Khojah
doaj   +1 more source

Prolonged glucocorticoid treatment in ARDS: impact on intensive care unit acquired weakness.

open access: yesFrontiers in Pediatrics, 2016
Systemic inflammation and duration of immobilization are strong independent risk factors for development of intensive care unit- acquired weakness (ICUAW).
Gianfranco Umberto Meduri   +2 more
doaj   +1 more source

WEAK SATURATION AND WEAK AMALGAMATION PROPERTY [PDF]

open access: yesThe Journal of Symbolic Logic, 2019
Abstract We study the two model-theoretic concepts of weak saturation and weak amalgamation property in the context of accessible categories. We relate these two concepts providing sufficient conditions for existence and uniqueness of weakly saturated objects of an accessible category ${\cal K}$ .
openaire   +4 more sources

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