Results 101 to 110 of about 1,403,195 (294)
THE CV OF THE WORLD'S SUPERPOWERS [PDF]
Revista Română de Geografie PoliticăWe already know that not all states can become world superpowers. Compared to Romania, the United States of America is 90 times more economically powerful, the European Union 60 times, while India or China are each 70 times more populated and Russia ...
Angelica NECȘULEA, Luca DIACONESCU
doaj +1 more source
City of Ideas: Reinventing Boston's Innovation Economy: The Boston Indicators Report 2012 [PDF]
, 2012 Analyzes indicators of the city's economic, social, and technological progress; potential for creating innovative solutions to global and national challenges; and complexities, disparities, and weaknesses in the indicators and innovation economy ...
Aditi Mehta +2 more
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Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Weaknesses of the Management System of Traditional Hungarian Universities [PDF]
Transformation of the management of traditional higher education institutions emerged in Hungary following the change of the political system in 1990, however, an appropriate answer has not been found to date.
Gabriella Keczer
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WEAK SATURATION AND WEAK AMALGAMATION PROPERTY [PDF]
The Journal of Symbolic Logic, 2019 Abstract We study the two model-theoretic concepts of weak saturation and weak amalgamation property in the context of accessible categories. We relate these two concepts providing sufficient conditions for existence and uniqueness of weakly saturated objects of an accessible category ${\cal K}$ .
openaire +4 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
مجله انفورماتیک سلامت و زیست پزشکی, 2020 Introduction: Wearable electronic devices, which are based on Internet of Things (IoT) and big data computing, are able to continuously collect and process the physiological and environmental data and exchange them with other tools, users, and internet ...
Zaiddodine Pashandi +2 more
doaj
Mechanisms of urban change: Regeneration companies or development corporations? [PDF]
, 2004 This article is an early assessment of the role and performance of URCs, benchmarked against the UDC model.
Greenhalgh, Paul, Gudgeon, C.
core
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source