Results 121 to 130 of about 1,403,195 (294)
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
An Analysis of Student Evaluations of Native and Non Native Korean Foreign Language Teachers [PDF]
Journal of the National Council of Less Commonly Taught Languages, 2009 In an effort to analyze the strengths and weaknesses of native and non-native teaching assistants and part-time teachers (both referred to as TAs in this article), students completed 632 evaluations of Ko-rean Language TAs from 2005 to 2008, and these ...
Julie Damron
doaj
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Developing theme and rheme in expository writing: A case study [PDF]
, 2007 Teaching writing to non-native speakers of English demands much more than appropriate sentence construction and grammar. Writing at the tertiary level involves thinking in the English way.
Wong, Eric T.K.
core
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Primer on Post-Claims Underwriting [PDF]
, 2009 Provides an overview of the practice of insurers investigating policy holders' medical histories after claims are submitted and canceling, rescinding, or limiting coverage.
core
Cryptanalysis of a new chaotic cryptosystem based on ergodicity
, 2008 This paper analyzes the security of a recent cryptosystem based on the ergodicity property of chaotic maps. It is shown how to obtain the secret key using a chosen-ciphertext attack.
CHENGQING LI +5 more
core +2 more sources