Results 131 to 140 of about 400,831 (317)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Students and the teaching of Arabic grammar at Jordanian schools [PDF]
The main purpose of this study is to explore the reasons for students' weaknesses in grammar at Jordanian schools, taking as an example the upper basic stage (ages 14-16 years) in the Al-karak district.
Al-Qudah, Hatem Ahmed
core
Reducing the risk of failure by deliberate weaknesses [PDF]
, 2020 The deliberate weaknesses are points of weakness towards which a potential failure is channelled in order to limit the magnitude of the consequences from failure.
Todinov, Michael
core
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Exergaming for Children and Adolescents: Strengths, Weaknesses, Opportunities and Threats [PDF]
, 2018 Exergaming, or active video gaming, has become an emerging trend in fitness, education and health sectors. It is defined as digital games that require bodily movements to play, stimulating an active gaming experience to function as a form of physical ...
Benzing, Valentin +3 more
core +1 more source
Revista de Ciencias Economicas, 2011 El presente trabajo muestra una serie de variables e indicadores empresariales que ofrecen un panorama general de las micro, pequeñas y medianas empresas (mipymes) de varios distritos y cantones de la región Pacífico Central: Puntarenas, Barranca ...
Susan Chen Mok, Kathia García Cousin
doaj
An Analysis of Student Evaluations of Native and Non Native Korean Foreign Language Teachers [PDF]
Journal of the National Council of Less Commonly Taught Languages, 2009 In an effort to analyze the strengths and weaknesses of native and non-native teaching assistants and part-time teachers (both referred to as TAs in this article), students completed 632 evaluations of Ko-rean Language TAs from 2005 to 2008, and these ...
Julie Damron
doaj
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source