Results 61 to 70 of about 1,403,195 (294)
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
ACTIVITIES TO ANTICIPATE THE WEAKNESSES OF STUDENTS’ READING MATERIALS FROM INTERNET
Lire Journal, 2020 The shift of the way of reading from printed material into non-printed material (reading from the computer, tablet, and smartphone) happened in the past few years ago.
Maria Eka Mulatsih
doaj +1 more source
Robust information from phylogenetic trees? [PDF]
, 2010 Traditional information criteria approaches can lead to misleading model choice in comparative phylogenetics. I present both these weaknesses and a more robust comparison by likelihood ratio.
Carl Boettiger
core +2 more sources
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
CONSIDERATIONS ON THE MODELS OF ECONOMIC DEVELOPMENT [PDF]
Annals of the University of Petrosani: Economics, 2022 This paper displays in detail the three large categories of successful economic development models worldwide: the Anglo-American model, the European model and the Asian model.
ROLAND-EDUARD KACSO-DOBOLY
doaj
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
What happens when coachees explore their strengths? [PDF]
International Journal of Evidence Based Coaching and Mentoring, 2011 Recent research largely focuses on measuring the outcomes of strengths-based coaching but fails to consider coachees’ individual experience of the process.
Teresa Clifford
doaj
The weak scale from weak gravity [PDF]
Journal of High Energy Physics, 2019 Abstract We explore the prospects for bounding the weak scale using the weak gravity conjecture (WGC), addressing the hierarchy problem by violating the expectations of effective field theory. Building on earlier work by Cheung and Remmen, we construct models in which a super-extremal particle satisfying the electric WGC for a new ...
Craig, Nathaniel +2 more
openaire +4 more sources
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source