Results 51 to 60 of about 8,041 (308)

A Factory of Bacterial Weaponry

ACADEMIA. The magazine of the Polish Academy of Sciences
Understanding one of the key virulence mechanisms of Porphyromonas gingivalis bacteria could lead to improved methods for preventing and treating periodontitis and related diseases.
Mikruta, Katarzyna, Madej, Mariusz
openaire   +2 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

UAV formation control based on distributed Kalman model predictive control algorithm

AIP Advances, 2022
To address the perturbation of formation of multiple unmanned aerial vehicles (UAVs) subject to external disturbances, an algorithm of distributed Kalman model predictive control is proposed in this paper to improve the accuracy of maintaining a ...
Qiangwei Pang, Yongyong Zhu, Ye Chen, Deshi Wang, Wenkai Suo   +4 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Radar Error Correlation Analysis Under the Simultaneous Observation of Double Targets

IEEE Access
Radar error is a significant factor restricting the detection accuracy of radar. Improving the detection accuracy of radar is crucial to accurate target localization in an ocean environment.
Yuxiang Zhou, Faxing Lu, Qiuyang Dai, Junfei Xu   +3 more
doaj   +1 more source

Ultrathin interferometric hydrophone towed line array based on uwFBG

AIP Advances, 2023
In order to improve the suitability of the fiber hydrophone towing line array, we propose an interferometric hydrophone towed line array with a diameter of 1.7 mm.
Su Wu, Hongcan Gu, Yandong Pang, Wen Liu, Jiabei Wang, Junbin Huang   +5 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Remote Weaponry: The Ethical Implications

, 2008
The nature of warfare is changing. Increasingly, developments in military technology are removing soldiers from the battlefield, enabling war to be waged from afar. Bombs can be dropped from unmanned drones flying above the range of retaliation. Missiles
KILLMISTER, S
core   +1 more source

Analysis of Characteristics of the Electric Field Induced by an Angularly Rotating and Oscillating Magnetic Object

Applied Sciences
A mathematical model for an electric field induced by an angularly oscillating magnetic dipole was proposed with magnetic vector potential to analyze the characteristics of the electric field induced by a rotating and angularly oscillating magnetic ...
Jiawei Zhang, Dawei Xiao, Taotao Xie, Qing Ji   +3 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source