Results 61 to 70 of about 10,288 (251)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Characteristics of Electric Field Induced by Oscillating Metal Underwater Vehicle

Applied Sciences
To analyze the induced electric field characteristics generated by the rotation and shaking of underwater metal vehicles, a mathematical model of the induced electric field generated by the underwater metal vehicles was derived using Faraday’s ...
Taotao Xie, Jiawei Zhang, Dawei Xiao, Qing Ji   +3 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Remote Weaponry: The Ethical Implications

, 2008
The nature of warfare is changing. Increasingly, developments in military technology are removing soldiers from the battlefield, enabling war to be waged from afar. Bombs can be dropped from unmanned drones flying above the range of retaliation. Missiles
KILLMISTER, S
core   +1 more source

Male contest competition and the coevolutionof weaponry and testes in pinnipeds [PDF]

, 2012
Male reproductive success is influenced by competitive interactions during precopulatory and postcopulatory selective episodes. Consequently, males can gain reproductive advantages during precopulatory contest competition by investing in weaponry and ...
Kolm, Niclas, Simmons, L. W., Almbro, M., Kolm, N., Almbro, Maria, Fitzpatrick, John L., Fitzpatrick, J.L., Kolm, Niclas,, Fitzpatrick, J. L., Gonzalez-Voyer, A., González-Voyer, Alejandro, Simmons, Leigh W.   +11 more
core   +1 more source

Analysis of Electromagnetic Field Characteristics of Wave Glider

Applied Sciences
A wave glider is an ocean observation platform that utilizes wave energy to drive and solar energy to power. Its metal structure will generate related electromagnetic fields due to corrosion and underwater motion. In the detection of weak electromagnetic
Taotao Xie, Jiawei Zhang, Dawei Xiao, Qing Ji   +3 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Direction-Finding Study of a 1.7 mm Diameter Towed Hydrophone Array Based on UWFBG

Sensors
This paper investigates a 1.7 mm diameter ultra-weak fiber Bragg grating (UWFBG) hydrophone towed array cable for acoustic direction finding. The mechanism of the underwater acoustic waves received by this integrated-coating sensitizing optical cable is ...
Su Wu, Junbin Huang, Yandong Pang, Jiabei Wang, Hongcan Gu   +4 more
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Pleistocene weaponry

Weaponry co-evolved with the genus Homo, providing a means with which to actively hunt. This review of the evidence of the use of weapons in the Pleistocene traces the development from one-piece wooden spears and throwing sticks through to innovative ...
Milks, Annemieke
core   +1 more source