Results 231 to 240 of about 192,161 (316)

System level network data and models attack cancer drug resistance

British Journal of Pharmacology, EarlyView.
Drug resistance is responsible for >90% of cancer related deaths. Cancer drug resistance is a system level network phenomenon covering the entire cell. Small‐scale interactomes and signalling network models of drug resistance guide directed drug development.
Márk Kerestély, Dávid Keresztes, Levente Szarka, Borbála M. Kovács, Klára Schulc, Dániel V. Veres, Peter Csermely   +6 more
wiley   +1 more source

RareLink: scalable REDCap-based framework for rare disease interoperability linking international registries to FHIR and Phenopackets. [PDF]

NPJ Genom Med
Graefe ASL, Rehburg F, Alkarkoukly S, Danis D, Grönke A, Hübner MR, Bartschke A, Debertshäuser T, Klopfenstein SAI, Saß J, Fleck J, Rehberg M, Zschüntzsch J, Nyoungui EF, Kalashnikova T, Murguía-Favela L, Derfalvi B, Wright NAM, Moosa S, Ogishima S, Semler O, Wiegand S, Kühnen P, Mungall CJ, Haendel MA, Robinson PN, Thun S, Beyan O.   +27 more
europepmc   +1 more source

Action Design Research for Actionable Knowledge Production: A Metareflexive Methodology for Digital Transformation and Innovation Studies

Creativity and Innovation Management, EarlyView.
ABSTRACT The sociotechnical complexities and hidden dynamics shaping the evolution of digital transformation (DT) and innovation initiatives frequently elude traditional research approaches reliant on retrospective analysis, static and detached observation.
Siobhán Diglas, Kisito F. Nzembayie
wiley   +1 more source

Knowledge Representation of a Multicenter Adolescent and Young Adult Cancer Infrastructure: Development of the STRONG AYA Knowledge Graph. [PDF]

JCO Clin Cancer Inform
Hogenboom J, Gouthamchand V, Cairns C, Janssen SHM, Way K, Dekker ALAJ, van der Graaf WTA, Darlington AS, Husson O, Wee LYL, van Soest J, Lobo Gomes A.   +11 more
europepmc   +1 more source

Children of Divorced Parents—The Limitations of One‐Size‐Fits‐All Interventions

Child &Family Social Work, EarlyView.
ABSTRACT The political agenda of the Danish School Reform in 2014 provides a heightened awareness of pupils' mental health–including children of divorced parents. The primary focus is to support children's emotion management, and in that regard, conversation groups are offered to children experiencing divorce.
Pernelle Rose Hansen
wiley   +1 more source

Protégé-OWL: Creating Ontology-Driven Reasoning Applications with the Web Ontology Language.

, 2005
Daniel L. Rubin, Holger Knublauch, Ray W. Fergerson, Olivier Dameron, Mark A. Musen   +4 more
openalex   +1 more source

Construction, Deployment, and Usage of the Human Reference Atlas Knowledge Graph. [PDF]

Sci Data
Bueckle A, Herr BW, Hardi J, Quardokus EM, Musen MA, Börner K.   +5 more
europepmc   +1 more source

Divorcescapes: Family Conflicts and Children's Lived Spaces

Child &Family Social Work, EarlyView.
ABSTRACT This article presents an analysis from a project that focuses on the entanglements that emerge between practices within the family law system and the everyday lives of children in conflictual family law cases. We position our analysis in critical childhood studies and zoom in on the social–spatial dimensions of children's everyday lives by ...
Hanne Warming, Sarah Alminde
wiley   +1 more source

‘I like to dance with the flowers!’: Exploring the possibilities for biodiverse futures in an urban forest school

Children &Society, EarlyView.
Abstract This article explores the ways in which ‘forest school’, an educational approach where children engage in creative and play based activities in a ‘natural’ environment, can contribute towards Sustainable Development Goal 15 (SDG 15) by promoting sustainable use of terrestrial ecosystems and by helping address biodiversity loss. Drawing on data
Hannah Hogarth
wiley   +1 more source

OLS4: a new Ontology Lookup Service for a growing interdisciplinary knowledge ecosystem. [PDF]

Bioinformatics
McLaughlin J, Lagrimas J, Iqbal H, Parkinson H, Harmse H.   +4 more
europepmc   +1 more source