Results 71 to 80 of about 3,409,142 (330)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

EFFECT OF WEB OPENING ON THE AXIAL LOAD CAPACITY OF STEEL COLUMNS WITH COLD FORMED THIN WALLED SECTION (CFS)

Kufa journal of Engineering, 2016
In this paper, an experimental study has been presented to investigate the effects of web opening on the behavior and failure of steel columns with cold formed thin walled sections (CFS) subjected to axial compressive load.
Sadjad Amir AlJallad, H. Al-Thairy
semanticscholar   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Numerical study of web crippling strength in cold-formed austenitic stainless steel lipped channels with web openings subjected to interior-two-flange loading [PDF]

, 2016
In cold-formed stainless steel lipped channel-sections, use of web openings for service purposes are becoming increasingly popular. Web openings, however, result in the sections becoming more susceptible to web crippling.
Clifton, G. C., Lim, J. B.P., Uzzaman, A., Young, B., Yousefi, A. M.   +4 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Analytical Study of Reinforced Concrete Continuous Deep Beams

Tikrit Journal of Engineering Sciences, 2010
Nonlinear finite element analyses is carried out using the ANSYS11 program to predict the ultimate load for two different types of reinforced concrete continuous two-span deep beams. Results of comparing analytical with experimental data demonstrates the
Hosam A. Dahaam, Omer F. Ibraheem
doaj   +1 more source

The Relevance of Open Data Principles for the Web of Data

Journal of Electrical and Computer Engineering, 2023
Open data has been improving both publishing platforms and the consumers-oriented process over the years, providing better openness policies and transparency. Although organizations have tried to open their data, the enrichment of their resources through
Jhon Francined Herrera-Cubides, Paulo Alonso Gaona-García, Carlos Enrique Montenegro-Marin, Salvador Sánchez-Alonso   +3 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Finite Element Analysis of Lateral Torsional Buckling Behaviour of Tapered Steel Section with Perforation

MATEC Web of Conferences, 2016
This paper presents the finite element analysis of lateral torsional buckling of tapered steel section with perforation. The numerical analysis consists of four main models with a ratio of tapering 0.3 for 3.5m and 5.5m span and ratio of tapering 0.5 for
Naaim Nurfarhah, De’nan Fatimah, Keong Choong Kok, Azar Faiz   +3 more
doaj   +1 more source

Elastic buckling of simply supported stiffened steel plates with circular opening

Journal of Engineering and Applied Science, 2022
Steel plates are used as the main components of steel elements in many structures. Openings in steel elements may exist for maintenance or inspection purposes in addition to creating paths for different fixtures such as air conditioning, pipes, and ...
Maha M. Hassan, Sara I. Mahmoud, Mohammed H. Serror, Ahmed F. Hassan   +3 more
doaj   +1 more source