Results 81 to 90 of about 2,101,874 (287)

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

A survey of QoS-aware web service composition techniques [PDF]

, 2014
Web service composition can be briefly described as the process of aggregating services with disparate functionalities into a new composite service in order to meet increasingly complex needs of users.
Epiphaniou, Gregory, Safdar, Ghazanfar Ali, Shehu, Umar Galadima   +2 more
core   +2 more sources

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

ANGELS: An Intelligent Gestational Follow-Up System

IEEE Access
The reduction of fetal, neonatal, and infant mortality rates is crucial in maternal and neonatal care. The UN’s 2030 Agenda aims for a better world by 2030, highlighting goal 3: healthy lives for all ages, with a focus on reducing global maternal ...
Elisson Da Silva Rocha, Cleber Matos De Morais, Igor Vitor Teixeira, Kayo Henrique De Carvalho Monteiro, Sebastiao Rogerio Da Silva Neto, Wembley Carvalho, Helio Rubens Soares, Rubem Saldanha, Waldemar Brandao Neto, Patricia Takako Endo   +9 more
doaj   +1 more source

Improving the network transmission cost of differentiated web services [PDF]

, 2005
This paper investigates into the transmission cost of web services related messages which is affected by network latency. Web services enable seamless interaction and integration of e-business applications.
Awan, Irfan U., Younas, M.
core  

Bio‐Orthogonally Crosslinked Supramolecular Polymer Bottlebrush Hydrogels for Long‐Term 3D Cell Culture

Advanced Functional Materials, EarlyView.
Fibrous benzenetrispeptide (BTP) hydrogels, fabricated via strain‐promoted azide‐alkyne cycloaddition (SPAAC) crosslinking, form robust, bioinert networks. These hydrogels can support 3D cell culture, where cell viability and colony growth depend on the fiber content.
Ceren C. Pihlamagi, David Pretzel, Peer Nölte, Kourosh Rezaei, Ulrich S. Schubert, Johannes C. Brendel   +5 more
wiley   +1 more source

PM4SWS: A P2P Model for Semantic Web Services Discovery and Composition

Journal of Advances in Information Technology, 2011
Since the beginning of the service oriented paradigm, the Web service discovery presents an important problem. Web Services should act autonomously with as minimal human intervention as possible, they should be able to discover other services which have ...
Mohamed Gharzouli, Mahmoud Boufaida
doaj   +1 more source

Controlling 3D Contractility via Engineered Fibrous Hydrogel Composites

Advanced Functional Materials, EarlyView.
A tunable composite contractile assembly (CCA) is developed that can permit or resist contraction without changing cell‐adhesion and density, unlike collagen whose inherent coupling of these ECM cues limits its use as a platform in contractility studies.
Karen L. Xu, Yuqi Zhang, Alysse DeFoe, Georgios Kotsaris, Brendan Stoeckl, Matthew D. Davidson, Jason A. Burdick, Robert L. Mauck   +7 more
wiley   +1 more source

Web Applications and Web Services: A Comparative Study

Science Journal of University of Zakho, 2018
Software components that rely on the Internet in order to be accessed and used cover many aspects of our daily activities including email checking, weather checking, purchase ordering, and Facebook logging.
Qusay I. Sarhan, Idrees S. Gawdan
doaj   +1 more source

Extending OWL-S for the Composition of Web Services Generated With a Legacy Application Wrapper [PDF]

, 2012
Despite numerous efforts by various developers, web service composition is still a difficult problem to tackle. Lot of progressive research has been made on the development of suitable standards.
Gibaud, Bernard, Wali, Bacem
core   +2 more sources