Results 41 to 50 of about 467,479 (314)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
LE PSEUDONYME : REFLET D’IDENTITE SUR LE WEB SOCIAL ? [PDF]
Studii de gramatică contrastivă, 2020 Cet article présente une réflexion sur l’identité et ses diverses formes de manifestations sur les plateformes socionumériques. Il ne sera pas ici question de traiter l’identité numérique dans sa totalité, mais il s’agira plutôt, pour nous, de nous ...
Achour Bourdache, Soufiane Lanseur
doaj
New perspectives on Web search engine research [PDF]
, 2012 Purpose–The purpose of this chapter is to give an overview of the context of Web search and search engine-related research, as well as to introduce the reader to the sections and chapters of the book.
Lewandowski, Dirk
core
Challenging social media analytics: Web Science perspectives
, 2014 In this paper we outline some of the challenges for social media analytics and -- at the same time - challenge existing approaches to social media analysis.
Pope, Catherine J +10 more
core +1 more source
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
Contabilidad y Negocios: Revista del Departamento Académico de Ciencias Administrativas, 2017 Organizations perceive electronic commerce, as a mechanism to reach their stakeholders directly, facilitating the success of the transaction and from anywhere in the world (Guzman, Gil & Carot 2013).
Alba Patricia Guzmán Duque +1 more
doaj
Folksonomies, the semantic web, and movie recommendation [PDF]
, 2007 While the Semantic Web has evolved to support the meaningful exchange ofheterogeneous data through shared and controlled conceptualisations, Web 2.0 has demonstrated that large-scale community tagging sites can enrich the semantic web with readily ...
C. CATTUTO +13 more
core
Web evolution and Web Science [PDF]
, 2012 This paper examines the evolution of the World Wide Web as a network of networks and discusses the emergence of Web Science as an interdisciplinary area that can provide us with insights on how the Web developed, and how it has affected and is affected ...
Tiropanis, Thanassis, Hall, Wendy
core +1 more source
FEBS Open Bio, EarlyView.Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta +7 more
wiley +1 more source