Results 111 to 120 of about 3,312,099 (267)

B4GALNT4‐Mediated Glycosylation of PDK1 Activates the PI3K‐AKT Signaling Pathway to Promote Prostate Cancer Progression

Advanced Science, EarlyView.
This study identifies B4GALNT4 as a key driver of prostate cancer (PCa). It shows that B4GALNT4 glycosylates PDK1 protein at the N531 site, which stabilizes the PDK1 and constitutively activates the PI3K‐AKT pathway. This mechanism promotes tumor cell proliferation, migration, and invasion. The findings establish the B4GALNT4‐PDK1 glycosylation axis as
Shaoqin Jiang, Mengqiang Li, Qingfu Su, Ruiling Dou, Shaoshan Lin, Jili Zhang, Xiaochen Sun, Haolan Yu, Wei Bao, Min Qu, Yan Wang, Chenghua Yang, Xu Gao   +12 more
wiley   +1 more source

Improving the Patient Colonoscopy Prep Experience [PDF]

, 2017
AIM: To improve patient prep compliance, prep quality, and an overall better experience by designing a prep specific website that will address the most common prep questions and concerns Once launched, the website address will be placed on printed ...
Cohen, MD, Robert, Cosgrove, MD, Natalie, Dargan, MD, Andrew, Dhanekula, MD, Raja K., Francis, MD, Gloria, Gandhi, MD, Komal, Kistler, MD, Andrew, Malamood, MD, Mark, Moleski, MD, Stephanie M., Niu, MD, Bolin, Prieto, MD, Jorge, Reddy, MD, Sheela S., Shah, MD, Apeksha, Tofani, MD, Christina, Zabolotsky, MD, Andrew   +14 more
core   +1 more source

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source

Designing a New Model for Organizational Websites Evaluation

International Journal of Information Science and Management, 2018
The current web evaluation models are mainly based on the technical evaluation of the site and its appearance and usability from user's perspective. In other words, the site is evaluated as an independent entity from the underlying organization that it ...
Abolfazl Sherafat, Sayyed Mohammad Reza Davoodi   +1 more
doaj  

Agile Scrum as a Development Approach: A Case Study of Web-based School Information System Design

Sistemasi: Jurnal Sistem Informasi
The growing utilization of information technology presents substantial opportunity to enhance efficiency in school administrative activities. Nevertheless, numerous educational institutions continue to employ semi-manual processes with software like ...
Rizky Wandri, M Rizki Fadhilah, Panji Rachmat Setiawan, Mutia Fadhilla   +3 more
doaj   +1 more source

Telomere‐to‐Telomere Genomes Reveal that Multiscale Evolution Shapes the Largest Metabolic Arsenal of Diaporthe Fungi

Advanced Science, EarlyView.
This study presents the first telomere‐to‐telomere genomes and population resources for Diaporthe pathogens, uncovering the largest known fungal repertoire of secondary metabolite gene clusters. Structural variations and horizontal gene transfer drive cluster diversification, while specific rapidly evolving clusters control virulence, offering novel ...
Kainan Li, Chen Zhang, Zhichao Zhang, Jiaheng Cheng, Qiuyan Gao, Long Gao, Xiaolin Zhao, Wei Yan, Yuanchao Wang, Wenwu Ye   +9 more
wiley   +1 more source

3D WEB BASED BINUS UNIVERSITY INTERNATIONAL SIMULATION AND DIRECTORY SYSTEM [PDF]

, 2012
3D WEB BASED BINUS UNIVERSITY INTERNATIONAL SIMULATION AND DIRECTORY SYSTEM - Usability research in 3D, 3D website, directory ...
NATALIA, LIENNY, Yaya Heryadi,
core  

Palmitoylation‐Mediated Ubiquitination of SRPK1 Regulates Ferroptosis in High‐Fat‐Induced Erectile Dysfunction

Advanced Science, EarlyView.
Elevated exogenous palmitic acid promotes the S‐palmitoylation of SRPK1 in endothelial cells, a dynamic process governed by ZDHHC24 and APT1. This post‐translational modification strengthens the interaction between SRPK1 and the E3 ubiquitin ligase MIB1, thereby facilitating the proteasomal degradation of SRPK1.
Xiao‐Hui Tan, Ke‐Fan Li, Yi‐Ming Yuan, Man‐Cheng Xia, Fang‐Zhou Zhao, Hong‐Gang Ying, Zhuo Zhou, Peng‐Chao Gao, Guo‐Qing Xie, Xue‐Song Li, Hui Jiang, Rui‐Li Guan   +11 more
wiley   +1 more source

ANALISIS USER EXPERIENCE WEBSITE INFO TECH (I-LAB) MENGGUNAKAN USER EXPERIENCE QUESTIONNAIRE (UEQ)(STUDI KASUS : UNIVERSITAS MUHAMMADIYAH MALANG) [PDF]

Teknologi saat ini sudah menunjukkan kemajuan yang sangat pesat, adapun faktor yang memicu perkembangan teknologi ini adalah kebutuhan manusia akan teknologi dan informasi yang cepat dan akurat.
Rizky, Mochamad
core  

Dorr Rebellion Project Selected Bibliography [PDF]

, 2014
An annotated and traditional bibliography of research materials utilized by Dr. Erik J. Chaput and Rhode Island scholar Russell J. DeSimone in creating the script for The Dorr Rebellion short-form documentary and other resources on the Dorr Rebellion ...
Chaput, Erik J., DeSimone, Russell J.
core   +1 more source