Results 111 to 120 of about 3,335,608 (290)
Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells
Advanced Science, EarlyView.ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen +11 more
wiley +1 more source
Assessment of laryngologists' ratings on physician review websites
World Journal of Otorhinolaryngology-Head and Neck SurgeryObjective To assess and characterize online ratings and comments on laryngologists and determine factors that correlate with higher ratings. Methods All the American Laryngological Association (ALA) members were queried across several online platforms ...
Meleeka Akbarpour +5 more
doaj +1 more source
Exploring the landscape of reflection [PDF]
, 2016 open4noopenFrison, Daniela; Fedeli, Monica; Tino, Concetta; Minnoni, ErikaFrison, Daniela; Fedeli, Monica; Tino, Concetta; Minnoni ...
Fedeli, Monica +3 more
core
Advanced Science, EarlyView.ABSTRACT Base editors enable precise genome modification and have emerged as a promising therapeutic approach for correcting diseases caused by single‐nucleotide variants. While the current efficient version of adenine base editors (ABEs), such as ABE8e, exhibits exceptional efficiency for A‐to‐G conversions, their clinical translation is hindered by ...
Jiawei Yao +12 more
wiley +1 more source
NoumericoThis research aims to develop website-based interactive learning media with the help of a wordwall on logarithm material. The research method uses Research and Development (R&D) with the ADDIE development model with stages of Analysis, Design ...
Zahroatul Fitroh, Zainullah Zuhri
doaj +1 more source
CNS Technology Website Administrative Guide (Version 1.0) [PDF]
, 2008 Air Force Office of Scientific Research (F49620-01-1-0397); National Science Foundation (SBE-0354378); Office of Naval Research (N00014-01-1-0624)
Carpenter, Gail A. +5 more
core +1 more source
Advanced Science, EarlyView.This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu +18 more
wiley +1 more source
Advanced Science, EarlyView.Upon NIR irradiation at 808 nm, the activity of TRPV4 was inhibited by M2M@BPSC, which led to reduced calcium influx, mitochondrial protection, and, importantly, the transcriptional activation of the STAT6‐EGR2 pathway. The improved macrophage function indirectly readjusts the equilibrium between C‐ECM and F‐ECM to reconstruct a suitable ...
Chenqi Yu +11 more
wiley +1 more source
Restoring Iron Homeostasis via Smoothened Inhibition: A Novel Strategy Against Hearing Loss
Advanced Science, EarlyView.. ABSTRACT Sensorineural hearing loss (SNHL) induced by noise or aminoglycoside antibiotics is a significant public health concern without any FDA‐approved pharmaceutical therapies. Dysregulation of iron homeostasis and its subsequently induced ferroptosis has increasingly been identified as a key mechanism underlying cochlear hair cell (HC) damage ...
Huanyu Mao +9 more
wiley +1 more source
Designing a New Model for Organizational Websites Evaluation
International Journal of Information Science and Management, 2018 The current web evaluation models are mainly based on the technical evaluation of the site and its appearance and usability from user's perspective. In other words, the site is evaluated as an independent entity from the underlying organization that it ...
Abolfazl Sherafat +1 more
doaj