Results 131 to 140 of about 659,210 (249)

Depletion of Sorcs3 Activates Totipotency in Mouse Embryonic Stem Cells by Modulating Key Signaling Pathways

open access: yesAdvanced Science, EarlyView.
In this article, Shuai and colleagues found that depletion of Sorcs3 could activate totipotency in mESCs, promising bidirectional differentiation potential to embryonic and extraembryonic lineages. The underlying mechanism might be activation of Tfap2c and repression of TGF‐β, PI3K‐AKT, and lysosome pathways.
Wenhao Zhang   +12 more
wiley   +1 more source

Retinoic Acid Reprograms Mast Cells Toward a Proinflammatory State to Enhance Antitumor Immunity

open access: yesAdvanced Science, EarlyView.
Proinflammatory mast cells represent an MHC‐IIhigh, cytokine‐producing mast cell subset associated with improved survival and enhanced responses to anti‐PD‐1 therapy. Retinoic acid drives their polarization, enabling antigen uptake and presentation, and T cell recruitment and activation, collectively promoting adaptive anti‐tumor immunity.
Lizao Zhang   +25 more
wiley   +1 more source

Search Engine Optimization for a Website (3PDigital.Co)

open access: hybrid, 2019
Abhijeet Joshi, Suhasini Vijaykumar
openalex   +1 more source

Nonalcoholic Fatty Liver Disease Exacerbates the Advancement of Renal Fibrosis by Modulating Renal CCR2+PIRB+ Macrophages Through the ANGPTL8/PIRB/ALOX5AP Axis

open access: yesAdvanced Science, EarlyView.
The ANGPTL8/PIRB/ALOX5AP axis mediates liver‐kidney crosstalk. Hepatocytes secrete ANGPTL8, which binds to CCR2+PIRB+ macrophages in the kidneys, affecting the expression of ALOX5AP and enhancing the activation of these macrophages. Activated cells produce TGF‐β, IL‐6, and IL‐23, driving Th17 activation and promote the formation of myofibroblasts ...
Shuqi Wei   +18 more
wiley   +1 more source

Nutritional c‐Fos Induction Rewires Hepatic Metabolism and Can Promote Obesity‐Associated Hepatocellular Carcinoma

open access: yesAdvanced Science, EarlyView.
It is shown that hepatic c‐Fos responds to feeding, altering de novo lipogenesis, glycolysis, and a wide range of steatosis‐associated metabolic signaling pathways. Obesogenic diets cause hepatic c‐Fos overexpression, insulin resistance, and the induction of metabolic reprogramming‐related genes.
Ao Li   +8 more
wiley   +1 more source

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