Results 51 to 60 of about 988,937 (294)

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Exploring Web Accessibility and Usability for Users with Attention Deficit Hyperactivity Disorder: Evaluation of Specific Guidelines and Adaptations

International Journal of Interactive Multimedia and Artificial Intelligence
Attention Deficit Hyperactivity Disorder (ADHD) presents specific cognitive and attentional characteristics that can significantly affect web navigation and information processing.
Lucía Alonso Virgós, Isabel Morales Gil, Luis Rodriguez Baena, Jordán Pascual Espada, Rubén González Crespo   +4 more
doaj   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

An Update on Foot and Ankle Fellowship Website Content and Accessibility

Foot & Ankle Orthopaedics, 2020
Background: The content and accessibility of foot and ankle fellowship websites impact applicants and fellowship programs. This study aimed to evaluate the accessibility provided via the American Orthopaedic Foot & Ankle Society (AOFAS) websites and ...
Ansab Khwaja MD, Peter Du MD, Nathan Sherman MD, MBA, Lisa Truchan MD   +3 more
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Evaluation models and criteria of the quality of hospital websites: a systematic review study

Electronic Physician, 2017
Introduction: Hospital websites are important tools in establishing communication and exchanging information between patients and staff, and thus should enjoy an acceptable level of quality.
Fatemeh Rangraz Jeddi, Hamidreza Gilasi, Sahar Khademi   +2 more
doaj   +1 more source

Assessment of a website aimed at providing information on mental health to secondary school students in Can Tho city, Vietnam

Child and Adolescent Psychiatry and Mental Health, 2021
Background The stigmatization of mental health problems is a primary barrier for young people to approach mental health services when they suspect they might have such problems.
Dat Tan Nguyen, Tam Thi Pham, E. Pamela Wright, Joske Bunders   +3 more
doaj   +1 more source

Taiwan’s E-Government Usability from Foreign Perspective and Website Accessibility amid COVID-19 Pandemic

Journal of Business and Behavioural Entrepreneurship, 2021
The aim of this research intends to investigate Taiwanese egovernment websites with regards to Accessibility and Usability. The automated WAVE Accessibility tool and Nielsen’s 10 Heurestic Principle based surveys of foreign users of the English ...
Husam ALmaghalsah
doaj   +1 more source

Accessibility on a Finnish city government website [PDF]

, 2023
Accessibility is an important, but often overlooked topic on the web that is slowly gaining importance in societies around the world as it allows people with a wide range of disabilities to use public services, and it also makes them much more usable for
Karasti, Juho
core  

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source