Results 131 to 140 of about 307,710 (264)

TSTScope Unifies Single‐Cell Multi‐Omics to Identify Functional T Cell States Predictive of Immunotherapy Response

Advanced Science, EarlyView.
TSTScope is an interpretable AI framework that integrates single‐cell transcriptomes with TCR information through curated gene‐program constraints. By linking receptor context to functional T cell states, it reveals response‐associated tumor‐specific T cell programs in lung cancer immunotherapy cohorts and defines an MPR score associated with ...
Shiwei Cao, Jinyu Cheng, Feng‐ao Wang, Chenxin Yi, Jiajun Chen, Keyue Wang, Lulu Liu, Junwei Liu, Yixue Li   +8 more
wiley   +1 more source

m6A‐Driven Pexophagy Triggers Placental Ferroptosis to Impair Fetal Growth Upon Environmental Stress

Advanced Science, EarlyView.
Prenatal environmental stress exposure promotes m6A modification to drive PEX2‐dependent pexophagy, thereby causing placental ferroptosis and FGR. ABSTRACT The role and underlying mechanisms of placental ferroptosis in fetal growth restriction (FGR) induced by environmental stress remain poorly understood.
Xin‐Xin Zhang, Ye‐Xin Luo, Cheng‐Fang Sun, Rui Pan, Yu‐Xi Wu, Zhi Yuan, Xin‐Run Wang, Xu‐Dong Zhang, Lan‐Lan Wu, Xiang‐Yu Yao, Zhan‐Dong Song, Wei Chang, Tian Wei, Pan‐Yuan Cai, Tian‐Ci Zhang, Yong‐Wei Xiong, De‐Xiang Xu, Hua Wang, Hua‐Long Zhu   +18 more
wiley   +1 more source

Systematic review of the quality, readability, and reliability of web-based pediatric neurosurgical patient education information. [PDF]

Childs Nerv Syst
Ogbonnah CO, Allbright ML, Rizk EB.
europepmc   +1 more source

Website Ratings of Physicians and Their Quality of Care [PDF]

JAMA Internal Medicine, 2015
Bradley M, Gray, Jonathan L, Vandergrift, Guodong Gordon, Gao, Jeffrey S, McCullough, Rebecca S, Lipner   +4 more
openaire   +2 more sources

Livestock Multi‐Omics Integration: A Systematic Framework From Statistical Association to Causal Interpretation

Advanced Science, EarlyView.
A three‐tier livestock multi‐omics framework resolves four typical analytical pitfalls. Moving from statistical association through machine learning preprocessing to triple‐modal causal inference, it converts omics results into genomic selection and gene editing strategies to achieve One Health, underpinned by multi‐omics data, multimodal sequencing ...
Jiying Wen, Zhongyu Wang, Jieping Huang, Fen Li, Ningbo Chen, Yun Ma   +5 more
wiley   +1 more source

The impact of online store specifications on enhancing the attractiveness of customer perception of the product: An analytical study of the opinions of a sample of Iraqi virtual store customers. [PDF]

F1000Res
Awni SA, Hammadi AA, Al-Halboosi IAM, Shakaterh HJM, Salman D, Ababneh AMNW, Stavytskyy A, Faleh Alazzam FA, Shakaterh RH.   +8 more
europepmc   +1 more source

Quantum‐Like Dynamics in Whole‐Brain Models of the Human Connectome

Advanced Science, EarlyView.
Quantum‐like dynamics in the human brain. The level of quantum‐like behavior in a non‐quantum system of coupled oscillators is regulated by the spectral gap of the coupling graph. Whole‐brain modelling using QL fits the empirical data significantly better and has a lower model‐derived energy cost than the non‐QL model.
Gustavo Deco, Yonatan Sanz Perl, Natasha Greenstein, Shamil Chandaria, Gregory Scholes, Morten L. Kringelbach   +5 more
wiley   +1 more source

Beyond Search Engine Optimization: How Large Language Models Are Redefining Surgeon Visibility. [PDF]

Plast Reconstr Surg Glob Open
Sorenson TJ, Boyd CJ, Hemal K, Cohen O, Karp N, Choi M.   +5 more
europepmc   +1 more source

Single‐Cell Profiling Reveals a Protective WNT5A‐ATF3‐FOSB Signaling Axis in Hair Follicle Stem Cells During Androgenetic Alopecia

Advanced Science, EarlyView.
Androgenetic alopecia (AGA) is a common form of hair loss with limited treatment options. Silencing of WNT5A signaling, which is widely known as the trigger of the ncWNT signaling pathway, happens in hair follicle stem cells from balding areas. It leads to downregulation of ATF3 and its target FOSB.
Ruiyu Luo, Ke Fang, Changjiang Zhao, Jiachao Xiong, Yuan Zhu, Mingyang Lu, He Yan, Zihan Li, Baojin Wu, Hua Jiang, Yufei Li   +10 more
wiley   +1 more source