Results 141 to 150 of about 256,079 (316)

Does More Bandwidth Really Not Matter (Much)? [PDF]

open access: yesarXiv
The prevailing wisdom is that more network bandwidth does not matter much and that website performance is primarily limited by network latency. However, as mobile websites become more complex and mobile network performance improves, does this adage continue to hold?
arxiv  

Dissecting the Spatial and Single‐Cell Transcriptomic Architecture of Cancer Stem Cell Niche Driving Tumor Progression in Gastric Cancer

open access: yesAdvanced Science, EarlyView.
A single‐cell and spatial transcriptional atlas reveals the architecture of human gastric cancer stem cell (CSC) niche and the developmental trajectory of CSCs. These CSCs interact with immunosuppressive immune cells thereby constructing immune‐suppressive niche, and inflammatory cancer‐associated fibroblast (iCAFs) to enhance stemness through ...
Guangyu Zhang   +17 more
wiley   +1 more source

Neural Patterns of Social Pain in the Brain‐Wide Representations Across Social Contexts

open access: yesAdvanced Science, EarlyView.
Empathy arises from both physiological and social pain, yet their shared and context‐specific neural mechanisms remain unclear. Combining fMRI and multivariate pattern analysis, this study decodes overlapping empathy networks and distinct representations for social exclusion versus separation.
Xiaodong Zhang   +11 more
wiley   +1 more source

Multimodal Locomotion: Next Generation Aerial–Terrestrial Mobile Robotics

open access: yesAdvanced Intelligent Systems, EarlyView., 2023
Aerial–terrestrial robots can achieve efficient energy consumption and robust environmental interaction by adding morphological features, adapting forms for locomotion transitions, and integrating multiple platforms. This next generation of mobile robots advances real‐world robotic deployment for operations with complex tasks and tackle environments ...
Jane Pauline Ramirez, Salua Hamaza
wiley   +1 more source

DAPK3 is Essential for DBP‐Induced Autophagy of Mouse Leydig Cells

open access: yesAdvanced Science, EarlyView.
This study has confirmed that death‐associated protein kinase 3 (DAPK3) is essential for dibutyl phthalate (DBP)‐induced autophagy of mouse Leydig cells, and is regulated by both transcription factor specific protein 2 (Sp2) and parkin RBR E3 ubiquitin‐protein ligase (PRKN), and melatonin can alleviate DBP‐induced autophagy of the cells.
Si Yang   +4 more
wiley   +1 more source

CXCL13 Damages Blood Spinal Cord Barrier by Promoting RNF6/Sqstm1‐Ubiquitination Induced Autophagy in Experimental Allergic Encephalomyelitis

open access: yesAdvanced Science, EarlyView.
In multiple sclerosis, the disruption of the blood‐spinal cord barrier (BSCB) induced by CXCL13 facilitates the infiltration of inflammatory cells into the central nervous system, resulting in demyelination and neuronal injury. Mechanistically, the deleterious impact of CXCL13 on the BSCB is associated with a reduction in tight junction protein ...
Jingjing Han   +10 more
wiley   +1 more source

ProteoSeeker: A Feature‐Rich Metagenomic Analysis Tool for Accessible and Comprehensive Metagenomic Exploration

open access: yesAdvanced Science, EarlyView.
ProteoSeeker is a new metagenomic analysis tool that accelerates protein discovery. By automating key steps, it reduces computational complexity and enables comprehensive dataset analysis, performing protein identification, screening based on user‐defined protein families, and taxonomic analysis.
Georgios Filis   +6 more
wiley   +1 more source

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