Results 181 to 190 of about 105,471 (295)

Tailored Dual Responsive Hybrid Gelatin Methacryloyl/Poly[2‐(Dimethylamino)Ethyl Methacrylate] Hydrogels for Efficient Ibuprofen Release in Topical Applications

open access: yesJournal of Applied Polymer Science, Volume 143, Issue 15, April 15, 2026.
GelMA/DMAEMA hybrid hydrogels for release of ibuprofen. ABSTRACT In this study, biocompatible hydrogels intended for topical delivery of ibuprofen were synthesized from gelatin methacryloyl (GelMA) and 2‐(dimethylamino)ethyl methacrylate (DMAEMA) by varying their proportions. The impact of different GelMA and DMAEMA ratios was comprehensively evaluated
Guilherme Frey Schutz   +7 more
wiley   +1 more source

Testing for Sufficient Follow‐Up in Survival Data With a Cure Fraction

open access: yesBiometrical Journal, Volume 68, Issue 2, April 2026.
ABSTRACT In order to estimate the proportion of “immune” or “cured” subjects who will never experience failure, a sufficiently long follow‐up period is required. Several statistical tests have been proposed in the literature for assessing the assumption of sufficient follow‐up, meaning that the study duration is longer than the support of the survival ...
Tsz Pang Yuen, Eni Musta
wiley   +1 more source

Longitudinal Tumor Size and Survival Modeling for Exposure–Response Analysis of Drugs with Frequent Dose Reductions: Dose Justification of Abemaciclib in Patients with Metastatic Breast Cancer

open access: yesClinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 1070-1079, April 2026.
Abemaciclib is an oral anticancer drug indicated for treatment of HR+ HER2‐ breast cancer. Dose modifications due to side effects are frequent, thus drug exposures change over time as a result of altering the dose or temporarily withholding abemaciclib treatment.
Emmanuel Chigutsa   +2 more
wiley   +1 more source

Acute and Chronic Toxicity of Sediments Containing Platinum and Palladium on Freshwater Benthic Organisms Chironomus riparius and Hyalella azteca

open access: yesJournal of Applied Toxicology, Volume 46, Issue 4, Page 1151-1163, April 2026.
ABSTRACT The expanding demand for platinum group elements (PGEs) in industrial and medical applications has led to their increasing accumulation in aquatic sediments. However, their ecological impacts remain poorly understood, particularly for sediment‐dwelling invertebrates. This study assessed the toxicity of platinum (Pt) and palladium (Pd) across a
Alice Carle   +3 more
wiley   +1 more source

Multivariate Tests for Comparing Lifetimes of Parallel Systems

open access: yesQuality and Reliability Engineering International, Volume 42, Issue 3, Page 1159-1171, April 2026.
ABSTRACT Life testing of engineering systems with dependent components requires robust multivariate methods. Parametric approaches depend on restrictive assumptions, limiting their use in complex or unknown lifetime distribution settings. This study evaluates nonparametric methods for comparing parallel system lifetimes under minimal sample ...
Niladri Chakraborty   +2 more
wiley   +1 more source

Optimal Accelerated Life Testing Design Under Constrained Resources Using Double Deep Q‐Learning

open access: yesQuality and Reliability Engineering International, Volume 42, Issue 3, Page 980-991, April 2026.
ABSTRACT Accelerated life tests (ALTs) are essential tools for estimating product reliability under high‐stress conditions, allowing failure data to be collected in reduced timeframes. However, planning effective ALT configurations is a complex task that requires selecting stress levels, test durations, and unit allocations while accounting for limited
Allan Jonathan da Silva   +3 more
wiley   +1 more source

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