Results 41 to 50 of about 68,425 (202)

Ixekizumab With Tirzepatide Achieved Greater Disease Control Than Ixekizumab Alone in Adults With Psoriatic Arthritis and Overweight or Obesity: Results From a Randomized Clinical Trial

Arthritis &Rheumatology, EarlyView.
Objective Overweight or obesity is prevalent in 72% to 82% of individuals with psoriatic arthritis (PsA). We assessed the efficacy and safety of ixekizumab (IXE) concomitantly administered with tirzepatide (TZP) compared with IXE alone in adult participants with active PsA and overweight with at least one weight‐related comorbidity or obesity.
Joseph F. Merola, Philip Mease, Alan Kivitz, Naveed Sattar, Laura C. Coates, Daniel Aletaha, Cynthia E. Kartman, Peter Fischer, Luna Sun, Píndaro Martínez‐Osuna, Andris Kronbergs, Purvi Prajapati, Anabela Cardoso, Mark C. Genovese, Alexis Ogdie   +14 more
wiley   +1 more source

Weight-adjusted-waist index: an innovative indicator of breast cancer hazard

BMC Women's Health
Background Central obesity and breast cancer (BC) have been identified as relevant by empirical research. The weight-adjusted-waist index (WWI) is a novel methodology for quantifying central obesity.
Xinyi Huang, Hengzheng Cheng, Laifu Deng, Shuting Wang, Jiaxiu Li, An Qin, Chunqiang Chu, Wenyi Du, Xiao Liu   +8 more
doaj   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

Exposure‐adjusted safety and efficacy of GLP‐I and GLP‐1/GIP receptor agonists compared with non‐GLP‐I for weight management and type 2 diabetes: Based on FDA medical and statistical reports of 34 280 safety and 36 312 efficacy subjects

British Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to contextualize glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and glucose‐dependent insulinotropic polypeptide (GIP) receptor agonists safety and efficacy regarding weight management (WM); we analysed Food and Drug Administration (FDA) Medical Reviews to analyse 14 medications using patient‐exposure year normalization and ...
Aishwarya Prasad, Anshu Arora, Arun Arora, Jeena Vaid, Arif Khan   +4 more
wiley   +1 more source

Nonlinear association between weight-adjusted-waist index and colorectal cancer in adults

Critical Public Health
Colorectal cancer (CRC) remains a major global health burden, with increasing incidence among younger adults. Obesity and visceral fat accumulation are known contributors to CRC risk, yet conventional anthropometric indices have limitations in accurately
Pinggang Ding, Zhengjiu Cui, Xin Liu, Lu Wang, Zhimin Fan   +4 more
doaj   +1 more source

Plasma Exosome Metabolomics Reveal Stage‐Specific Alterations in Elderly Women With Premetabolic and Metabolic Syndrome

Chronic Diseases and Translational Medicine, EarlyView.
Shared differential metabolites identified across the three sample groups. (A) Venn diagram of differential metabolites between the two comparison groups; Based on the detected levels of these overlapping differential metabolites, (B) d‐Arabitol, (C) Triclosan, (D) Iloprost, (E) Tetracosanoic acid, and (F) Omeprazole sulfone. Box plots were constructed
Mengtao Qian, Dan Nie, Qianyi Gao, Xingbo Mo, Huan Zhang   +4 more
wiley   +1 more source

Tick‐Tock, the Time Has Come: Leveraging TikTok to Understand, Prevent, and Treat Eating Disorders

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective TikTok—a highly engaging social media platform with a powerful algorithm that displays short videos—has become massively popular in recent years. As research highlights the concerning relationship between image‐based content on social media and disordered eating symptoms, TikTok may serve as an optimal platform to understand eating ...
Macarena Kruger, Isabella Pruscino, Caroline G. Martin, Elizabeth A. Velkoff   +3 more
wiley   +1 more source

Ecological Momentary Interventions in the Management of Eating Disorders and Obesity: A Systematic Review

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective This systematic review evaluated the feasibility, efficacy, adherence, and methodological quality of ecological momentary intervention (EMI)–based treatments for individuals with diagnosed eating disorders (EDs) and/or obesity. Method Eight electronic databases were systematically searched from inception to January 2026.
Wenlu Mao, Ricarda Schmidt, Emily K. Presseller, Adrienne Juarascio, Anja Hilbert   +4 more
wiley   +1 more source

Multivariate linear regression to predict association of non‐invasive arterial stiffness with cardiovascular events

ESC Heart Failure, Volume 12, Issue 2, Page 1141-1150, April 2025.
Abstract Background Arterial stiffness is a crucial factor in determining an increase in systolic blood pressure and pulse pressure and can also predict the development of cardiovascular disease (CVD). The purpose of this study was to examine the relationship between arterial stiffness and future CVD.
Susan Darroudi, Mostafa Eslamiyeh, Amin Mansoori, Eisa Nazar, Maryam Alinezhad‐Namaghi, Reza Rezvani, Majid Ghayour‐Mobarhan, Habibollah Esmaily, Mohsen Moohebati, Gordon A. Ferns, Mark Ghamsary   +10 more
wiley   +1 more source

Association between weight-adjusted waist index and bone mineral density in adolescents

Scientific Reports
The negative effects of obesity and excess body fat on bone mineral density (BMD) have been widely reported. As opposed to waist circumference (WC) or body mass index (BMI), weight-adjusted waist index (WWI) is a superior method for assessing obesity ...
Guoliang Ma, Bo Xu, Dian Zhang, Liguo Zhu, Yili Zhang, Bowen Yang, Xiaokuan Qin, He Yin, Xu Wei   +8 more
doaj   +1 more source