Results 101 to 110 of about 391,469 (311)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

In Vivo Corrosion of Two Novel Magnesium Alloys ZEK100 and AX30 and Their Mechanical Suitability as Biodegradable Implants [PDF]

, 2011
In magnesium alloys, the components used modify the alloy properties. For magnesium implants in contact with bone, rare earths alloys are commonly examined.
Angrisani, Nina, Bormann, Dirk, Huehnerschulte, Tim Andreas, Meyer-Lindenberg, Andrea, Rittershaus, Dina, Windhagen, Henning   +5 more
core   +3 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Analysis of Symmetry of Weight-Bearing in Athletes With and Without Low Back Pain during Gait

Annals of Applied Sport Science, 2018
Background. Low Back Pain (LBP) is a prevalent phenomenon in athletes and asymmetrical loading on the limbs has been proposed as a risk factor related to this disease. Objectives.
Meissam Sadeghisani, Vahid Sobhani, Hadi Azimi, Mohammad Taghi Karimi   +3 more
doaj  

The effect of weight-bearing training with visual feedback on balance and prosthetic loading in trans-tibial amputees following vascular disease – a pilot randomized control trial

Annals of Medicine
Purpose Asymmetrical weight-bearing on trans-tibial prosthesis at the initial prosthetic fitting results in a modified gait and secondary disorders. The pilot study will examine the feasibility of the weight-bearing training with visual feedback in trans-
Imre Cikajlo, Jovana Mitić, Helena Burger   +2 more
doaj   +1 more source

Do Patellofemoral Pain Patients Have Higher Loading Rate Compared to Healthy Indivalues? A Systematic Review and Meta-analysis

Physical Treatments, 2022
Purpose: Higher loading rates have been associated with injuries, plantar fasciitis, tibia bone stress injuries, knee osteoarthritis, and patellofemoral pain (PFP). The aim of this study is to evaluate the loading rate in PFP patients compared to healthy
Mohamadreza Ahmadi, Ali Yalfani
doaj  

The Cartilaginous Tissue Regeneration on Weight Bearing and Non-weight Bearing Surfaces of the Knee

, 2022
Regeneration of articular cartilage is a major problem in the field of orthopedic surgery and regenerative medicine. Most research on cartilage regeneration performed on rabbits, tests the possibilities of cartilage regeneration on the non-weight bearing surfaces of the distal femur - in the trochlear groove of the femur, giving less importance to the ...
Cobzac, V.P., Jian, M.V., Globa, T.G., Nacu, V.E.   +3 more
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Combining textured insoles and compelled body weight shift improves lower limb function and gait in individuals with stroke: a randomised controlled trial

Human Movement
Purpose To assess the effects of combining textured insoles (TI; plantar somatosensory stimulation) with compelled body weight shift (CBWS) on lower limb motor function, gait, and sensory function in stroke patients.
Adamu Adamu Ahmad, Duangporn Suriyaamarit, Akkradate Siriphorn   +2 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source