Results 71 to 80 of about 4,029,403 (298)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Enhanced cognitive behaviour therapy for adolescents with eating disorders: development, effectiveness, and future challenges

BioPsychoSocial Medicine
Eating disorders can significantly impact the psychosocial functioning and physical health of adolescents. Early and effective treatment is crucial to prevent long-lasting and potentially devastating adverse effects. The National Institute for Health and
Riccardo Dalle Grave, Simona Calugi
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Probing deformation mechanisms of CoCrFeNiMn0.75Cu0.25 highentropy alloy after thermo-mechanical treatment using in situ EBSD investigation

Journal of Materials Research and Technology
In this study, the CoCrFeNiMn0.75Cu0.25 high-entropy alloy (HEA) was systematically investigated to elucidate the effects of different annealing temperatures on the microstructure and mechanical properties of the face-centered cubic (fcc) structural ...
Wujing Fu, Jingwei Ren, Guohua Fan, Xuewen Li, Yongjiang Huang   +4 more
doaj   +1 more source

Is the Energy Homeostasis System Inherently Biased Toward Weight Gain? [PDF]

, 2003
Michael W. Schwartz, Stephen C. Woods, Randy J. Seeley, Gregory S. Barsh, Denis G. Baskin, Rudolph L. Leibel   +5 more
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Barriers to Care for Pediatric Patients with Obesity

Life
This review article emphasizes the challenges pediatric patients face during obesity treatment. Prior research has been compartmentalized, acknowledging that stigma, the ability to implement lifestyle changes, social health determinants, and healthcare ...
Sreevidya Bodepudi, Malikiya Hinds, Kayla Northam, Noreen A. Reilly-Harrington, Fatima Cody Stanford   +4 more
doaj   +1 more source

Management of Severe Rhabdomyolysis and Exercise-Associated Hyponatremia in a Female with Anorexia Nervosa and Excessive Compulsive Exercising

Case Reports in Medicine, 2016
This case report describes the management of a 49-year-old female with restricting-type anorexia nervosa and excessive compulsive exercising associated with rhabdomyolysis, high levels of serum creatine kinase (CK) (3,238 U/L), and marked hyponatremia ...
Marwan El Ghoch, Simona Calugi, Riccardo Dalle Grave   +2 more
doaj   +1 more source

A Longitudinal Study on the Effect of Shift Work on Weight Gain in Male Japanese Workers [PDF]

, 2008
Yasushi Suwazono, Mirei Dochi, Kouichi Sakata, Yasushi Okubo, Mitsuhiro Oishi, Kumihiko ­Tanaka, Etsuko Kobayashi, Teruhiko Kido, Kōji Nogawa   +8 more
openalex   +1 more source