Results 81 to 90 of about 13,390,811 (365)

Indices of O-regular variation for weight functions and weight sequences

, 2018
A plethora of spaces in Functional Analysis (Braun-Meise-Taylor and Carleman ultradifferentiable and ultraholomorphic classes; Orlicz, Besov, Lipschitz, Lebesque spaces, to cite the main ones) are defined by means of a weighted structure, obtained from a
Jiménez-Garrido, Javier, Sanz, Javier, Schindl, Gerhard   +2 more
core   +1 more source

Microstructure and Mechanical Properties of Ultrafine-Grained Dual-Phase 0.1C3Mn Steel Processed by Warm Deformation

Metals
In this study, we have explored the thermomechanical processing on 0.1C3Mn steel to produce an ultrafine-grained (UFG) dual-phase (DP) microstructure. The composition was designed to allow a decrease in temperature for the warm deformation of austenite ...
Yongkang Wang, Chenglu Liu, Qingquan Lai
doaj   +1 more source

Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284

FEBS Letters, EarlyView.
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli, Alex Fissore, Edoardo Salladini, Eleonora Raccuia, Simonetta Oliaro‐Bosso, Alessia Ruggiero, Rita Berisio, Milagros Medina, Adrian Velazquez‐Campoy, Salvatore Adinolfi, Mauro Marengo   +10 more
wiley   +1 more source

Weight-Preserving Simulated Tempering [PDF]

, 2019
Simulated tempering is popular method of allowing MCMC algorithms to move between modes of a multimodal target density {\pi}. One problem with simulated tempering for multimodal targets is that the weights of the various modes change for different ...
Roberts, Gareth O., Rosenthal, Jeffrey S., Tawn, Nicholas G.   +2 more
core   +2 more sources

The Patient’s Journey in Obesity within the United States: An Exercise of Resilience against Disease

Life
Obesity is often viewed as a result of patient failure to adhere to healthy dietary intake and physical activity; however, this belief undermines the complexity of obesity as a disease.
Kayla Northam, Malikiya Hinds, Sreevidya Bodepudi, Fatima Cody Stanford   +3 more
doaj   +1 more source

Patients' reasons for weight loss and their relations to clinical weight loss outcomes in a comprehensive lifestyle intervention

Obesity Science & Practice, 2019
Summary Objective Research suggests that individuals seeking weight loss treatment do so for a variety of reasons. Limited work has explored relations of reasons for weight loss to patient characteristics or to weight loss outcomes.
Leah Boepple, Ian Cero, Ryan J. Marek, Sandra Coulon, Janet A. Lydecker, Joshua D. Brown, Robert Malcolm, Patrick M. O'Neil   +7 more
doaj   +1 more source

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source

Archaeal protein containing domain of unknown function 2193 undergoes oligomeric reconfiguration upon iron–sulfur cluster binding

FEBS Letters, EarlyView.
This work presents the characterization of MvoDUF2193, a Methanococcus voltae (Mvo) protein from the domain of unknown function (DUF) 2193 family. We demonstrate that MvoDUF2193 binds a single [4Fe–4S] cluster per subunit and that cluster occupancy regulates the transition from an apo tetramer to a [4Fe–4S] monomeric form. This structural transition is
Emily M. Dieter, James Larson, Monika Tokmina‐Lukaszewska, Jin Xiong, Jared Green, Yisong Guo, William E. Broderick, Brian Bothner, Joan B. Broderick   +8 more
wiley   +1 more source

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen   +8 more
wiley   +1 more source

Budget reviews and commissions of audit in Australia [PDF]

Examining the origins, conduct, conclusions of, and reactions to, previous budget reviews provides some indications about how the current National Commission of Audit might unfold.
Daniel Weight
core