Results 31 to 40 of about 172,080 (203)

Missing the target: including perspectives of women with overweight and obesity to inform stigma‐reduction strategies

Obesity Science & Practice, 2017
Summary Objective Pervasive weight stigma and discrimination have led to ongoing calls for efforts to reduce this bias. Despite increasing research on stigma‐reduction strategies, perspectives of individuals who have experienced weight stigma have rarely
R. M. Puhl, M. S. Himmelstein, A. A. Gorin, Y. J. Suh   +3 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Beyond forced translation: obesity, disability and the case for autonomous protection against weight discrimination

Frontiers in Public Health
Legal and public health debates on obesity move between three distinct objects: a clinical condition, a functional limitation, and a process of social exclusion.
Raúl Sampieri-Cabrera, Raúl Sampieri-Cabrera, Karen Soldatic   +2 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Evidence-based recommendations to assist adults with depression to become lifelong movers

Health Promotion and Chronic Disease Prevention in Canada, 2020
IntroductionWeight-related social stigma is associated with adverse health outcomes. Health care systems are not exempt of weight stigma, which includes stereotyping, prejudice and discrimination.
Gupta, Neeru, Bombak, Andrea, Foroughi, Ismael, Riediger, Natalie   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The role of psychological attribution in responses to weight stigma

Obesity Science & Practice, 2020
Summary Objective Weight discrimination is associated with numerous negative health consequences. Little is known about early‐stage psychological mechanisms that explain variability in responses to weight discrimination among people with obesity.
Mary A. Gerend, Angelina R. Sutin, Antonio Terracciano, Jon K. Maner   +3 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Weight-Based Health Care Discrimination and Cervical Cancer Screening Among Black Sexual and Gender Minoritized Assigned Female at Birth Adults in the United States

Health Equity
Introduction: Black sexual and gender minoritized (SGM) people assigned female at birth (AFAB) face notable barriers to cervical cancer screening, including racism, heterosexism, and cisgenderism.
Simran Singh, Neil Mehta, Madeline Noh, Keosha Bond, Megan Threats, John W. Jackson, Nkiru Nnawulezi, Marquisele Mercedes, Madina Agénor   +8 more
doaj   +1 more source

The target/perpetrator brief-implicit association test (B-IAT): an implicit instrument for efficiently measuring discrimination based on race/ethnicity, sex, gender identity, sexual orientation, weight, and age

BMC Public Health, 2021
Background To date, research assessing discrimination has employed primarily explicit measures (i.e., self-reports), which can be subject to intentional and social desirability processes.
Maddalena Marini, Pamela D. Waterman, Emry Breedlove, Jarvis T. Chen, Christian Testa, Sari L. Reisner, Dana J. Pardee, Kenneth H. Mayer, Nancy Krieger   +8 more
doaj   +1 more source