Results 141 to 150 of about 7,387,955 (262)
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Portrait of Jim Conway, 2003 [picture] /
Title from inscription.; Inscriptions: "Greg Weight 2003"--In pencil lower right on verso; "Jim Conway 2003"--In pencil lower left on verso; Embossed stamp with photographer's initials lower right.; Also available in an electronic version via the ...
Weight, Greg, 1946-
core
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Generalized Hamming Weight as a Weight Function
We prove that the weight function of a linear code, that is, an integer function defined on the vector space of messages, uniquely determines the code up to equivalence. We propose a natural way to extend the r-th generalized Hamming weight, that is, a function on r-subspaces of a code, to a function on the r-th exterior power of the code.
openaire +1 more source
Title from caption on item.; Inscriptions: Larger print: "Judy Cassab 1993" - in pencil on reverse l.l. corner. "Photograph Greg Weight 1993" - in pencil on reverse l.r. corner.
Weight, Greg, 1946-
core
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
Two exponential-trigonometric Hardy-Hilbert-type integral inequalities in the whole plane [PDF]
Christophe Chesneau
doaj +1 more source
On some fractional order hardy inequalities
Weighted inequalities for fractional derivatives ( fractional order Hardy-type inequalities) have recently been proved in [4] and [1]. In this paper, new inequalities of this type are proved and applied. In particular, the general mixed norm case and a
Kufner Alois +2 more
doaj

