Results 41 to 50 of about 2,675,508 (307)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

CYP2D6 Genetic Variation and Antipsychotic-Induced Weight Gain: A Systematic Review and Meta-Analysis

Frontiers in Psychology, 2022
BackgroundAntipsychotic-induced weight gain is a contributing factor in the reduced life expectancy reported amongst people with psychotic disorders. CYP2D6 is a liver enzyme involved in the metabolism of many commonly used antipsychotic medications.
Yanisa Wannasuphoprasit, Stig Ejdrup Andersen, Maria J. Arranz, Maria J. Arranz, Rosa Catalan, Rosa Catalan, Gesche Jurgens, Sanne Maartje Kloosterboer, Henrik Berg Rasmussen, Henrik Berg Rasmussen, Anjali Bhat, Haritz Irizar, Dora Koller, Dora Koller, Renato Polimanti, Renato Polimanti, Baihan Wang, Eirini Zartaloudi, Isabelle Austin-Zimmerman, Isabelle Austin-Zimmerman, Elvira Bramon, Elvira Bramon, Elvira Bramon, Elvira Bramon   +23 more
doaj   +1 more source

A comparison of finishing strategies to fixed slaughter weights for Holstein Friesian and Belgian Blue × Holstein Friesian steers [PDF]

, 2010
peer-reviewedCattle finishing strategies may involve feeding a high energy diet throughout or following a period of moderate growth. The objective of this study was to compare Holstein Friesian (HF) and Belgian Blue × Holstein Friesian (BB) steers (24 ...
Keane, Michael G.
core  

Weight Gain, Obesity, and Psychotropic Prescribing

Journal of Obesity, 2011
A majority of psychiatric medications are known to generate weight gain and ultimately obesity in some patients. There is much speculation about the prevalence of weight gain and the degree of weight gain during acute and longitudinal treatment with ...
Nikhil Nihalani, Thomas L. Schwartz, Umar A. Siddiqui, James L. Megna   +3 more
doaj   +1 more source

Advice about weight gain during pregnancy and actual weight gain. [PDF]

American Journal of Public Health, 1986
In the 1980 National Natality Survey, married mothers were asked whether their doctors had suggested a weight gain limit during pregnancy and, if so, what limit was suggested. Current obstetric recommendations call for 22-27 pound weight gain. Previous research indicates that gaining less than 16 pounds greatly increases the likelihood of a poor ...
S M, Taffel, K G, Keppel
openaire   +2 more sources

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

Associations of Weight Change With Changes in Calf Muscle Characteristics and Functional Decline in Peripheral Artery Disease. [PDF]

, 2019
Background Among people with lower extremity peripheral artery disease, obesity is associated with faster functional decline than normal weight. The association of weight loss with functional decline in peripheral artery disease is unknown.
Bazzano, Lydia A, Criqui, Michael H, Ferrucci, Luigi, Guralnik, Jack M, Kibbe, Melina R, Leeuwenburgh, Christiaan, McDermott, Mary M, Polonsky, Tamar S, Sufit, Robert L, Tian, Lu, Zhang, Dongxue   +10 more
core  

Preventing weight gain with calorie-labeling [PDF]

, 2014
Objective: Calorie-labeling has been suggested as an anti-obesity measure but there is no evidence for its effect, to date. Early adulthood is a critical life-cycle period for unwanted weight gain and obesity development.
Hankey, Catherine Ruth, Lean, Michael Ernest John, Nikolaou, Charoula Konstantia   +2 more
core   +1 more source

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

Assessment of Birth Weight and Its Related Factors among Infants Born in the Hospitals of Ahwaz Jondishapour University [PDF]

Journal of Health Sciences and Surveillance System, 2014
Background: Given the importance of birth weight and the effects of anthropometric indices and socioeconomic status on it, this study was conducted to assess birth weight and its related factors among infants born in the hospitals of Ahwaz Jondishapour ...
Shiva Faghih, ehsan hejazi
doaj