Results 61 to 70 of about 2,645,661 (354)

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

The impact of setting a pregnancy weight gain goal on total weight gain

Paediatric and Perinatal Epidemiology, 2020
AbstractBackgroundExpert groups recommend that women set a pregnancy weight gain goal with their care provider to optimise weight gain.ObjectiveOur aim was to describe the concordance between first‐trimester personal and provider pregnancy weight gain goals with the Institute of Medicine (IOM) recommendations and to determine the association between ...
Lisa M. Bodnar, Barbara Abrams, Hyagriv N. Simhan, Christina M. Scifres, Robert M. Silver, Samuel Parry, Brian A. Crosland, Judith Chung, Katherine P. Himes   +8 more
openaire   +5 more sources

Psychosocial and Biological Factors Contributing to Body Weight Gain in Schizophrenia [PDF]

, 2011
Overweight and obesity are frequently reported to be a significant issue in schizophrenia resulting in the inherent complications of these disorders.
Pai, NB, Vella, SC
core   +2 more sources

Changes in body weight and food choice in those attempting smoking cessation: a cluster randomised controlled trial [PDF]

, 2012
<p><b>Background:</b> Fear of weight gain is a barrier to smoking cessation and significant cause of relapse for many people. The provision of nutritional advice as part of a smoking cessation programme may assist some in smoking ...
AAWA van der Heijen, AC Parsons, Andrew Walker, AR Dyer, C Filozoff, Catherine R Hankey, F Pistelli, G Colletti, Heather M Murray, J Armstrong, J Stevens, JE Audrain, JE Cade, L Bauld, LR Purslow, MD Levine, MEJ Lean, MG Perri, Mhairi Mackenzie, Michael EJ Lean, P Hajek, Preethi R Koshy, R Ara, RC Klesges, S Chinn, S Rossner, St Stewart, Susan Boyle, Wilma S Leslie   +28 more
core   +3 more sources

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Causes and Consequences of Interdialytic weight gain

Kidney & Blood Pressure Research, 2016
Background/Aims: Higher interdialytic weight gain (IDWG) is associated with higher predialysis blood pressure and increased mortality. IDWG is also increasingly being recognized as an indicator of nutritional status. We studied in detail the associations
Karin J.R. Ipema, Johanna Kuipers, Ralf Westerhuis, Carlo A.J.M. Gaillard, Cees P. van der Schans, Wim P. Krijnen, Casper F.M. Franssen   +6 more
doaj   +1 more source

Visual disturbances and weight gain [PDF]

Postgraduate Medical Journal, 2001
Abstract A 51 year old man presented with a two year history of gradually deteriorating vision in his left eye, accompanied by 34 kg weight gain, easy bruising, and hypertension which was relatively resistant to conventional treatment. The patient denied any history of headaches. On examination, his general appearance was as shown (fig 1)
S, Sharma, R, Granot, N, Thomas, G A, Wilcsek, C, White, R, Fitzsimons, J, Tidmarsh, B E, Tuch   +7 more
openaire   +2 more sources

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Existing awareness of healthy weight gain during pregnancy in rural population of Solapur, Maharashtra, India

MRIMS Journal of Health Sciences, 2020
Antenatal care in rural population has been studied extensively in India. There is lack of data showing current awareness of weight gain during pregnancy in rural population of Solapur, Maharashtra, India.
Komal Gangar, Meher Chahal, Madhavi Rayate   +2 more
doaj   +1 more source