Results 81 to 90 of about 2,884,337 (241)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Carbohydrate reduction for metabolic disease is distinct from the ketogenic diet for epilepsy

Journal of Metabolic Health
Recent reviews of using therapeutic carbohydrate reduction to treat metabolic disease in paediatric patients have consistently made errors in the form of bias against recommending this nutrient-dense eating pattern despite strong evidence for its use in ...
Matthew Calkins, Laura Buchanan, Tro Kalayjian, David Dikeman, Mark Cucuzzella, Eric Westman   +5 more
doaj   +1 more source

Assessment of Physical Fitness after Bariatric Surgery and Its Association with Protein Intake and Type of Cholecalciferol Supplementation

Medicina, 2019
Background and objectives: Several studies showed that there is a relationship between vitamin and mineral status and muscle strength. In particular this is the case for handgrip strength (HS) and vitamin D deficiency.
Hendrika J. M. Smelt, Sjaak Pouwels, Alper Celik, Adarsh Gupta, Johannes F. Smulders   +4 more
doaj   +1 more source

Perspectives into the experience of successful, substantial long-term weight-loss maintenance: a systematic review

International Journal of Qualitative Studies on Health & Well-Being, 2021
Purpose: In light of the increasing prevalence of overweight and obesity, understanding the experiences, strategies and challenges encountered when trying to achieve substantial, sustainable weight loss is an important area to investigate.
Marie Spreckley, Jaap Seidell, Jutka Halberstadt   +2 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Effects of Diet Composition and Insulin Resistance Status on Plasma Lipid Levels in a Weight Loss Intervention in Women. [PDF]

, 2016
BackgroundOptimal macronutrient distribution of weight loss diets has not been established. The distribution of energy from carbohydrate and fat has been observed to promote differential plasma lipid responses in previous weight loss studies, and insulin
Flatt, Shirley W, Heath, Dennis D, Le, Tran, Natarajan, Loki, Pakiz, Bilge, Quintana, Elizabeth L, Rana, Brinda K, Rock, Cheryl L   +7 more
core   +3 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Obesidad, el papel del gastroenterólogo

Revista Colombiana de Gastroenterología
Antecedentes: la obesidad es una enfermedad con alta prevalencia a nivel mundial, y su incidencia está en aumento, especialmente en los países de ingresos medios a altos. Su fisiopatología se encuentra relacionada con la regulación hormonal intestinal y
Valeria Atenea Costa Barney, Daniela Caceres, Alfonso Kerguelen, Jesus Rodriguez, Andres Rodriguez, Manoel Galvao Neto   +5 more
doaj   +1 more source

Examining a Ripple Effect: Do Spouses’ Behavior Changes Predict Each Other’s Weight Loss? [PDF]

, 2013
Background. Including spouses in obesity treatment has been found to promote weight loss. We assessed whether spouses’ diet and activity changes impacted each other’s weight loss when both members attended an active weight loss program (TOGETHER) or only
Gorin, Amy A., McClure Brenchley, Kimberly, Schierberl Scherr, Anna E.   +2 more
core   +3 more sources