Results 81 to 90 of about 8,342,732 (338)

Mechanisms underlying the weight loss effects of RYGB and SG: similar, yet different

Journal of Endocrinological Investigation, 2018
The worldwide obesity epidemic continues unabated, adversely impacting upon global health and economies. People with severe obesity suffer the greatest adverse health consequences with reduced life expectancy.
Andrea Pucci, Rachel L. Batterham, Rachel L. Batterham   +2 more
semanticscholar   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Obesidad, el papel del gastroenterólogo

Revista Colombiana de Gastroenterología
Antecedentes: la obesidad es una enfermedad con alta prevalencia a nivel mundial, y su incidencia está en aumento, especialmente en los países de ingresos medios a altos. Su fisiopatología se encuentra relacionada con la regulación hormonal intestinal y
Valeria Atenea Costa Barney, Daniela Caceres, Alfonso Kerguelen, Jesus Rodriguez, Andres Rodriguez, Manoel Galvao Neto   +5 more
doaj   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Bariatric Surgery and Long-term Durability of Weight Loss.

JAMA Surgery, 2016
Importance Bariatric surgery induces significant weight loss for severely obese patients, but there is limited evidence of the durability of weight loss compared with nonsurgical matches and across bariatric procedures.
M. Maciejewski, D. Arterburn, Lynn van Scoyoc, V. Smith, W. Yancy, H. Weidenbacher, E. Livingston, M. Olsen   +7 more
semanticscholar   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Stressful weight loss [PDF]

Archives of Disease in Childhood - Education and Practice, 2010
This paper describes a patient initially diagnosed with autoimmune thyroiditis who undergoes a diagnostic and investigatory journey.
openaire   +3 more sources

Comparative Effectiveness and Safety of Bariatric Procedures for Weight Loss

Annals of Internal Medicine, 2018
In the past decade, there has been a dramatic shift in surgical procedures performed for weight loss in the United States (1). Although Roux-en-Y gastric bypass (RYGB) predominated through the late 2000s, sleeve gastrectomy (SG) has surpassed it in the ...
D. Arterburn, R. Wellman, A. Emiliano, Steven R. Smith, Andrew O Odegaard, Sameer B. Murali, Neely A Williams, K. Coleman, A. Courcoulas, R. Y. Coley, Jane Anau, Roy Pardee, S. Toh, Cheri Janning, A. Cook, J. Sturtevant, Casie E. Horgan, K. McTigue   +17 more
semanticscholar   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source