Results 131 to 140 of about 632,681 (338)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Weighted Average Power Similar Tests for Structural Change for the Gaussian Linear Regression Model [PDF]

open access: yes
The average exponential tests for structural change of Andrews and Ploberger (Econometrica, 62, 1994) and Andrews, Lee and Ploberger (Journal of Econometrics 70, 1996) and modifications thereof maximize a weighted average power which incorporates ...
Giovanni Forchini
core  

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

open access: yesFEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin   +3 more
wiley   +1 more source

On the Convergence of a Family of Chlodowsky Type Bernstein-Stancu-Schurer Operators

open access: yesJournal of Function Spaces, 2018
We construct a new family of univariate Chlodowsky type Bernstein-Stancu-Schurer operators and bivariate tensor product form. We obtain the estimates of moments and central moments of these operators, obtain weighted approximation theorem, establish ...
Lian-Ta Shu, Guorong Zhou, Qing-Bo Cai
doaj   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

open access: yesFEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata   +13 more
wiley   +1 more source

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

open access: yesAging and Cancer, EarlyView.
This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha   +4 more
wiley   +1 more source

Approximation by weighted Durrmeyer-type max-product neural network operators

open access: yesDemonstratio Mathematica
This paper introduces a class of weighted Durrmeyer-type max-product neural network operators, which generalize the Kantorovich variant by incorporating a flexible weight function.
Wu Yile, Yu Dansheng
doaj   +1 more source

Weighted Approximation by Szász–Mirakyan–Durrmeyer Operators Reproducing Exponential Functions

open access: yesMathematics
We examine a Szász–Mirakyan–Durrmeyer type operator that reproduces the functions 1 and e2ax for a fixed parameter a>0. While its exponential reproduction property has been described in the classical literature, the effect of exponential weights on its ...
Gülsüm Ulusoy Ada, Ali Aral
doaj   +1 more source

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