Results 141 to 150 of about 96,570 (315)
Weighted Majorization Algorithms for Weighted Least Squares Decomposition Models [PDF]
For many least-squares decomposition models efficient algorithms are well known. A more difficult problem arises in decomposition models where each residual is weighted by a nonnegative value.
Groenen, P.J.F. +2 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Stabilizing Weighted Graphs [PDF]
, 2018 An edge-weighted graph G is called stable if the value of a maximum-weight matching equals the value of a maximum-weight fractional matching. Stable graphs play an important role in some interesting game theory problems, such as network bargaining games ...
Koh, Cedric
core
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Approximation by weighted Durrmeyer-type max-product neural network operators
Demonstratio MathematicaThis paper introduces a class of weighted Durrmeyer-type max-product neural network operators, which generalize the Kantorovich variant by incorporating a flexible weight function.
Wu Yile, Yu Dansheng
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Banach Spaces of Analytic Vector-valued Functions [PDF]
, 2007 The main theme of the thesis is the study of continuity and approximation problems, involving matrix-valued and vector-valued Hardy spaces on the unit disc ID and its boundary T in the complex plane.
Barclay, Steven John
core
Approximation of Discrete Data by Discrete Weighted Transform
Journal of Mathematical Extension, 2014 The aim of this paper is to introduce the notion of discrete and inverse discrete weighted transform. We show that discrete input data can be converted to a continuous approximation through the inverse discrete weighted ...
S. Jahed, F. Javadi∗
doaj
Weighted Approximation by Szász–Mirakyan–Durrmeyer Operators Reproducing Exponential Functions
MathematicsWe examine a Szász–Mirakyan–Durrmeyer type operator that reproduces the functions 1 and e2ax for a fixed parameter a>0. While its exponential reproduction property has been described in the classical literature, the effect of exponential weights on its ...
Gülsüm Ulusoy Ada, Ali Aral
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source