Results 221 to 230 of about 4,043,038 (284)

An Interpretable, Data‐Driven, Hierarchical Multi‐Domain Fusion Framework for Classification and Motor Function Scoring in Chronic Ankle Instability

Advanced Science, EarlyView.
An AI‐enabled digital twin framework integrates wearable EMG sensing with hierarchical multi‐domain fusion to classify chronic ankle instability, distinguish clinically relevant subtypes, and generate continuous motor function scores. Clinically interpretable functional stratification and SHAP‐based biomarker analysis provide transparent decision ...
Tianle Jie, Datao Xu, Zhifeng Zhou, Bas Van Hooren, Huiyu Zhou, Yi Yuan, Xiangli Gao, Monèm Jemni, Liangliang Xiang, Meizi Wang, Justin Fernandez, Tibor J. Goda, Yaodong Gu   +12 more
wiley   +1 more source

Adaptive kNN graph model. [PDF]

Nat Commun
Li J, Xu H, Zhang S.
europepmc   +1 more source

WTAP Transcriptional Suppression by KLF9 Drives Osteoclastogenesis via M6A‐Mediated Regulation of CSF1R Signaling in Estrogen‐Deficient Osteoporosis

Advanced Science, EarlyView.
Scheme of the KLF9/WTAP/YTHDF2/m6A/CSF1R regulatory axis in osteoclastogenesis and estrogen‐deficient osteoporosis. WTAP‐mediated m6A modification of Csf1r mRNA governs osteoclastogenesis via a YTHDF2‐mediated pathway. Pathological upregulation of KLF9 drives Wtap transcription, leading to increased m6A deposition on the 3’‐UTR of Csf1r mRNA.
Chen Shen, Xin Liu, Gaoran Ge, Li Xu, Ziyu Zhang, Chang Lv, Hao Xu, Wenhao Li, Yi Qin, Qifeng Sheng, Qihan Wang, Hongxia Li, Jun Zhou, Huilin Yang, Dechun Geng   +14 more
wiley   +1 more source

Authoritative Textbook-Augmented Large Language Models for High-Altitude Public Health Medical Education in the Xizang Autonomous Region: Cross-Sectional Comparative Evaluation Study. [PDF]

J Med Internet Res
He K, Xiao Q, Chen W, Jing L, Wang Y, Li S, Yang D, Xu H, Pang K, Xiao R, Liu Z, Zhuoga D, Chen R, Li J, Chang L, Zhou Y, Zhang Z, Li R, Ying L, Li R, Wang H, Yin X, Zhen G, Cai S, Shan Q, Wang Q, Zhuoga D, Yangjin C, Luobu G, Ji T, Wu D.   +30 more
europepmc   +1 more source

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

An aging essential 8: closing the gap between geroscience and the public it serves. [PDF]

Biogerontology
Grimolizzi F.
europepmc   +1 more source

Artificial Intelligence in Spiritual Care: Modified Delphi Study. [PDF]

J Med Internet Res
Winiger F, Smith CE, Nourriz S, Szilagyi C, Haußmann A.   +4 more
europepmc   +1 more source

FedHSFV: Federated Learning for Finger Vein Recognition via Hierarchical Decoupling and Subspace Metric. [PDF]

Sensors (Basel)
Zhou X, Wang Y, Cui J, Guo J, Ren H.
europepmc   +1 more source

Analysis of phylogenetic signal in protein language model embeddings. [PDF]

Sci Rep
Stakauskas B, Górecki P.
europepmc   +1 more source

Integrating Clinical, Functional, and Patient-Reported Outcomes in Haemophilia Care: A Delphi-Based Consensus on a New Monitoring Tool. [PDF]

J Clin Med
Molinari AC, Baldacci E, Barillari G, Coluccia A, Coppola A, Giuffrida AC, Giuffrida G, Gorio C, Linari S, Luciani M, Catini A, Nichele I, Peyvandi F, Pollio B, Tagliaferri A, Valeri F, Villa MR, Zanon E, Napolitano M.   +18 more
europepmc   +1 more source