Results 71 to 80 of about 530,949 (219)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Robust Weighted Timed Automata and Games [PDF]

, 2013
Weighted timed automata extend timed automata with cost variables that can be used to model the evolution of various quantities. Although cost-optimal reachability is decidable (in polynomial space) on this model, it becomes undecidable on weighted ...
Markey, Nicolas, Patricia Bouyer, Ocan Sankur, Bouyer, Patricia, Sankur, Ocan, Nicolas Markey   +5 more
core   +1 more source

Integrated Multi-Mode Image-Based Corrosion Assessment and Probabilistic Reliability Framework for Steel Tower Structures Under Uncertainty

Buildings
Corrosion-driven section loss in steel tower structures erodes load-carrying capacity, yet field assessment still relies on subjective visual grading.
Hao Zhu, Chunli Ying, Yulong Chen, Jun Chen, Daguang Han   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Causes of degradation and erosion of a blanket mire in the southern Pennines, UK [PDF]

, 2006
This study investigates the causes of erosion and degradation of March Haigh, a blanket mire in the southern Pennines (UK), over a period of 160 years starting in 1840 AD.
J.C. Labadz, Labadz, J.C., C.O. Hunt, Yeloff, D., Hunt, CO, Hunt, C.O., Labadz, JC, D.E. Yeloff, Yeloff, DE   +8 more
core   +2 more sources

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Precision pesticide application in solanaceous crops using transfer learning explainable artificial intelligence and drone based spatial zone mapping

Discover Artificial Intelligence
Blanket pesticide spraying remains the default response to foliar disease in much of smallholder and mid-scale agriculture, despite three decades of precision-agriculture research arguing that inputs should be applied only where they are needed.
Jigneshkumar P. Desai
doaj   +1 more source

Integrated Bayesian Networks and Linear Programming for Decision Optimization

Mathematics
This paper develops a general BN → LP framework for decision optimization under complex, structured uncertainty. A Bayesian network encodes causal dependencies among drivers and yields posterior joint probabilities; a linear program then reads expected ...
Assel Abdildayeva, Assem Shayakhmetova, Galymzhan Baurzhanuly Nurtugan   +2 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source