Aging and Cancer, EarlyView.This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho +4 more
wiley +1 more source
Oscillatory dynamics as the coordination layer of the organism: waves, Markov blankets, and the virtual space of cognition. [PDF]
Front NeurosciDaniel TD.
europepmc +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
An Evidence-Based and Lived Experience Approach to Improving Therapeutic Environments for Neurodivergent Clients. [PDF]
Health Serv InsightsCominotti A, Green C.
europepmc +1 more source
Aging and Cancer, EarlyView.Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi +3 more
wiley +1 more source
Frail older people with insomnia experiences of using weighted blankets : a qualitative study
Background: Insomnia is common among frail older people living in nursing homes, and many are often prescribed medication. However, it may be beneficial to consider using a weighted blanket as an alternative intervention. Aim: The aim of the study was to
Hjort-Telhede, Eva, +2 more
core
The Effect of Limiting Anterior Chest Wall Movement With a Weighted Blanket on Comfort, Oxygenation, and Ventilation Homogeneity in Nonventilated Infants and Children Admitted to Hospital With Lower Respiratory Tract Infections: An Exploratory Pilot Study. [PDF]
Pediatr PulmonolLozano-Ray E +3 more
europepmc +1 more source
Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi +8 more
wiley +1 more source
Enhancing Pulp Therapy Outcomes in Children with Autism: A Sensory-adapted Dental Environment Approach. [PDF]
Int J Clin Pediatr DentPanigrahi A, Mohapatra A.
europepmc +1 more source
SPG4 and Dementia: Expanding the Clinical Spectrum
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza +19 more
wiley +1 more source