Results 61 to 70 of about 35,359 (261)
An algebraic framework of weighted directed graphs [PDF]
International Journal of Mathematics and Mathematical Sciences, 2003 We show that an algebraic formulation of weighted directed graphs leads to introducing a k‐vector space equipped with two coproducts Δ and verifying the so‐called coassociativity breaking equation . Such a space is called an L‐coalgebra. Explicit examples of such spaces are constructed and links between graph theory and coassociative coalgebras are ...
openaire +3 more sources
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
APPLICATION OF GRAPH THEORY TO BIOLOGICAL PROBLEMS
Studia Universitatis Babes-Bolyai Chemia, 2016 In this paper, we investigate application of graph theory to some biological problems, specially reconstructing strings based on information about their substrings and sequence comparison by using overlap graphs and also weighted directed graph.
Nafiseh JAFARZADEH, Ali IRANMANESH
doaj
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Skew Randi'c matrix and skew Randi'c energy [PDF]
Transactions on Combinatorics, 2016 Let $G$ be a simple graph with an orientation $sigma$, which assigns to each edge a direction so that $G^sigma$ becomes a directed graph. $G$ is said to be the underlying graph of the directed graph $G^sigma$.
Ran Gu, Fei Huang, Xueliang Li
doaj
An Improved Ant Colony Optimization Approach for Optimization of Process Planning
The Scientific World Journal, 2014 Computer-aided process planning (CAPP) is an important interface between computer-aided design (CAD) and computer-aided manufacturing (CAM) in computer-integrated manufacturing environments (CIMs).
JinFeng Wang, XiaoLiang Fan, Haimin Ding
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
A GNN-Based Log Anomaly Detection Framework with Prompt Learning for Edge Computing
ComputersSystem logs have been critical for analyzing the operational status and abnormal behavior of highly distributed and heterogeneous edge computing nodes.
Xianlang Hu +4 more
doaj +1 more source