Results 81 to 90 of about 35,359 (261)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Finite-Time Consensus with a Time-Varying Reference State and Switching Topology

Complexity, 2017
The finite-time consensus problem in the networks of multiple mobile agents is comprehensively investigated. In order to resolve this problem, a novel nonlinear information exchange protocol is proposed.
Jian-Yong Wang, Zhen Tian, Xu Zhu, Naif D. Alotaibi   +3 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Consensus over Weighted Directed Graphs: A Robustness Perspective

CoRR, 2016
The present paper investigates the robustness of the consensus protocol over weighted directed graphs using the Nyquist criterion. The limit to which a single weight can vary, while consensus among the agents can be achieved, is explicitly derived. It is shown that even with a negative weight on one of the edges, consensus may be achieved.
Dwaipayan Mukherjee, Daniel Zelazo
openaire   +2 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

GTST: A Python Package for Graph Two-Sample Testing

Journal of Open Research Software
The GTST package is a python package for performing graph sample testing. The test infers whether two samples of graphs were generated from the same probability distribution or not.
Ragnar L. Gudmundarson, Gareth W. Peters
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

A Weighted Diffusion Graph Convolutional Network for Relation Extraction

Journal of Electrical and Computer Engineering
Currently, graph convolutional network (GCN) is widely used in relation extraction (RE) tasks. Within RE tasks in the form of directed graphs, the placement of entities in the sentence context generates a large number of remote entity nodes in the ...
Jiusheng Chen, Zhenlin Li, Hang Yu, Xiaoyu Zhang   +3 more
doaj   +1 more source

On an asymptotic optimization problem in finite, directed, weighted graphs

Information and Control, 1968
This paper is concerned with finite, directed, branch-weighted graphs, where each weight is a real number bearing the connotation of “payoff.” The “average payoff” of a k-branch path is defined as the sum of the weights along this path divided by k. It is shown that, as k approaches infinity, the maximum average payoff obtainable with paths initiating ...
Irving L. Traiger, Arthur Gill
openaire   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source