Results 61 to 70 of about 1,935,881 (268)

Weight exchange in distributed learning

2016 International Joint Conference on Neural Networks (IJCNN), 2016
Neural networks may allow different organisations to extract knowledge from the data they collect about a similar problem domain. Moreover learning algorithms usually benefit from being able to use more training instances. But the parties owning the data are not always keen on sharing it.
Dorner, Julian, Favrichon, Samuel, Öğrenci, Arif Selçuk   +2 more
openaire   +3 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Molecular Weight Distribution of Proteins [PDF]

Nature, 1946
THE recent publication1 of an examination of Svedberg's theory of molecular weight distribution, in which the theory is considered to be invalid, suggests that a treatment, similar in some of its details, might be of interest. This was prepared in 19442, and the conclusions agree with those of Johnston, Longuet-Higgins and Ogston1, and with those of ...
openaire   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Three-dimensional parton distribution functions $g_{1T}$ and $h_{1L}^\perp$ in the polarized proton-antiproton Drell-Yan process

, 2011
We present predictions of the unweighted and weighted double spin asymmetries related to the transversal helicity distribution $g_{1T}$ and the longitudinal transversity distribution $h_{1L}^\perp$, two of eight leading-twist transverse momentum ...
A. Airapetian, A. Airapetian, A.M. Kotzinian, A.V. Efremov, B.-Q. Ma, B.-Q. Ma, B.-Q. Ma, B.-Q. Ma, B.-Q. Ma, B.-Q. Ma, B.-Q. Ma, Bo-Qiang Ma, D. Boer, D. Florian de, D. Florian de, E. Leader, F. Rathmann, H. Gao, I. Schmidt, J. Blumlein, J. Pumplin, J. She, J. Zhu, J. Zhu, Jiacai Zhu, M. Anselmino, M. Hirai, M.G. Alekseev, P. Lenisa, P.J. Mulders, S. Arnold, S.J. Brodsky, T. Huang, V. Barone, V. Barone, V.F. Dmitriev, V.Y. Alexakhin, X. Chen, X. Qian, Y. Huang, Z. Lu, Z. Lu, Z. Lu   +42 more
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Minimizing Induced Drag with Weight Distribution, Lift Distribution, Wingspan, and Wing-Structure Weight

AIAA Aviation 2019 Forum, 2019
ABSTRACTBecause the wing-structure weight required to support the critical wing section bending moments is a function of wingspan, net weight, weight distribution, and lift distribution, there exists an optimum wingspan and wing-structure weight for any fixed net weight, weight distribution, and lift distribution, which minimises the induced drag in ...
W.F. Phillips, D.F. Hunsaker, J.D. Taylor   +2 more
openaire   +7 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source