Results 71 to 80 of about 1,935,881 (268)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Limit Distribution for The Weighted Rank Correlation Coefficient, rw
Revstat Statistical Journal, 2006 A weighted rank correlation coefficient, inspired by Spearman’s rank correlation coefficient, has been proposed recently by Pinto da Costa & Soares [5].
Joaquim F. Pinto da Costa +1 more
doaj +1 more source
Weight distribution of the crown-weight space
European Journal of Combinatorics, 2007 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Kim, Dae San, Cho, Sung Hee
openaire +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
ON THE MEASUREMENT OF A COSMOLOGICAL DIPOLE IN THE PHOTON NUMBER COUNTS OF GAMMA-RAY BURSTS
, 1995 If gamma-ray bursts are cosmological or in a halo distribution their properties are expected to be isotropic (at least to 1st order). However, our motion with respect to the burst parent population (whose proper frame is expected to be that of the Cosmic
Boldt, E., Jahoda, K., Scharf, C. A.
core +1 more source
Credibility Distribution Estimation with Weighted or Grouped Observations
RisksIn non-life insurance practice, actuaries are often faced with the challenge of predicting the number of claims and claim amounts to be incurred at any given time, which serve to implement fair pricing and reserves given the nature of the risk.
Georgios Pitselis
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
On the spectral distribution of large weighted random regular graphs [PDF]
, 2013 McKay proved that the limiting spectral measures of the ensembles of $d$-regular graphs with $N$ vertices converge to Kesten's measure as $N\to\infty$. In this paper we explore the case of weighted graphs.
Goldmakher, Leo +3 more
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