Results 71 to 80 of about 5,236 (261)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Riemann–Liouville Operator in Weighted L_p Spaces via the Jacobi Series Expansion

Axioms, 2019
In this paper, we use the orthogonal system of the Jacobi polynomials as a tool to study the Riemann−Liouville fractional integral and derivative operators on a compact of the real axis.
Maksim V. Kukushkin
doaj   +1 more source

Estimates for Fractional Integral Operators and Linear Commutators on Certain Weighted Amalgam Spaces

Journal of Function Spaces, 2020
In this paper, we first introduce some new classes of weighted amalgam spaces. Then, we give the weighted strong-type and weak-type estimates for fractional integral operators Iγ on these new function spaces.
Hua Wang
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

On the Behaviors of Rough Fractional Type Sublinear Operators on Vanishing Generalized Weighted Morrey Spaces

International Journal of Analysis and Applications, 2019
The aim of this paper is to get the boundedness of rough sublinear operators generated by fractional integral operators on vanishing generalized weighted Morrey spaces under generic size conditions which are satisfied by most of the operators in harmonic
Ferit Gurbuz
doaj   +2 more sources

Endpoint boundedness for commutators of singular integral operators on weighted generalized Morrey spaces

Journal of Inequalities and Applications, 2020
In this paper, we obtain the endpoint boundedness for the commutators of singular integral operators with BMO functions and the associated maximal operators on weighted generalized Morrey spaces.
Jinyun Qi, Xuefang Yan, Wenming Li
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

On weighted dyadic Carleson's inequalities

Journal of Inequalities and Applications, 2001
We give an alternate proof of weighted dyadic Carleson's inequalities which are essentially proved by Sawyer and Wheeden. We use the Bellman function approach of Nazarov and Treil.
Tachizawa K
doaj  

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Sustainable bioplastics manufacturing from renewable sources

FEBS Open Bio, EarlyView.
Bioplastics are manufactured by using polymers from different bio‐based sources. These novel materials not only offer biodegradability but also possess various functional properties that make them suitable for diverse applications. Recent developments in the preparation of bioplastics are reported, highlighting the distinct properties of each type of ...
C. Valeria L. Giosafatto, Marika Avitabile, Michela Famiglietti, Talayeh Kordjazi, Marzieh Moosavi‐Nasab, Odile F. Restaino, Loredana Mariniello   +6 more
wiley   +1 more source