Results 71 to 80 of about 1,053,925 (307)
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Jackknifing Weighted Least Squares Estimators
Journal of the Royal Statistical Society Series B: Statistical Methodology, 1989 SUMMARY In a heteroscedastic linear regression model, the ordinary jackknife estimator of the asymptotic covariance matrix of the weighted least squares estimator is proved to be inconsistent. A modified jackknife procedure is proposed and shown to produce consistent estimators of the asymptotic covariance matrix.
openaire +2 more sources
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
Weighted Least Squares Regression with the Best Robustness and High Computability
AxiomsA novel regression method is introduced and studied. The procedure weights squared residuals based on their magnitude. Unlike the classic least squares which treats every squared residual as equally important, the new procedure exponentially down-weights
Yijun Zuo, Hanwen Zuo
doaj +1 more source
An optimized fractional grey model based on weighted least squares and its application
AIMS Mathematics, 2023 The fractional grey model is an effective tool for modeling small samples of data. Due to its essential characteristics of mathematical modeling, it has attracted considerable interest from scholars.
Caixia Liu , Wanli Xie
doaj +1 more source
FEBS Open Bio, EarlyView.Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava +3 more
wiley +1 more source
A continuous updating weighted least squares estimator of tail dependence in high dimensions [PDF]
Extremes, 2016 Likelihood-based procedures are a common way to estimate tail dependence parameters. They are not applicable, however, in non-differentiable models such as those arising from recent max-linear structural equation models.
J. Einmahl, A. Kiriliouk, J. Segers
semanticscholar +1 more source
FEBS Open Bio, EarlyView.We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source
Least Squares Approach to Locally Weighted Naive Bayes Method
Journal of New Results in Science, 2012 This study proposes a new approach which calculates the weights of Locally Weighted Naive Bayes (LWNB) developed on Naive Bayes (NB) which is known with its simple structure.
Kemal Adem, Onur Comert, Umut Orhan
doaj
Determination of Personalized IOL-Constants for the Haigis Formula under Consideration of Measurement Precision. [PDF]
PLoS ONE, 2016 The capabilities of a weighted least squares approach for the optimization of the intraocular lens (IOL) constants for the Haigis formula are studied in comparison to an ordinary least squares approach. The weights are set to the inverse variances of the
Simon Schröder +4 more
doaj +1 more source