Results 71 to 80 of about 235,360 (278)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Partitioned Maclaurin symmetric mean operators in bipolar complex fuzzy sets for multiattribute decision making

Scientific Reports
Mathematical tools are crucial for dealing with uncertainty because they provide a rigorous and logical framework for evaluating, measuring, and making decisions in the presence of ambiguous information.
Ubaid ur Rehman, Ibrahim Aldayel, Meraj Ali Khan, Tahir Mahmood   +3 more
doaj   +1 more source

Intuitionistic Fuzzy Normalized Weighted Bonferroni Mean and Its Application in Multicriteria Decision Making

Journal of Applied Mathematics, 2012
The Bonferroni mean (BM) was introduced by Bonferroni six decades ago but has been a hot research topic recently since its usefulness of the aggregation techniques. The desirable characteristic of the BM is its capability to capture the interrelationship
Wei Zhou, Jian-min He
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Linguistic neutrosophic Hamacher aggregation operators and the application in evaluating land reclamation schemes for mines. [PDF]

PLoS ONE, 2018
Land reclamation has become a significant way for the improvement of ecological environment in mining areas. When selecting the optimal land reclamation scheme, LNNs (linguistic neutrosophic numbers) are suitable to describe the complex fuzzy evaluation ...
Weizhang Liang, Guoyan Zhao, Suizhi Luo
doaj   +1 more source

Using fuzzy numbers and OWA operators in the weighted average and its application in decision making [PDF]

, 2009
Se presenta un nuevo método para tratar situaciones de incertidumbre en los que se utiliza el operador OWAWA (media ponderada – media ponderada ordenada). A este operador se le denomina operador OWAWA borroso (FOWAWA).
Casanovas Ramón, Montserrat, Cossío Silva, Francisco José (Coordinador), Merigó Lindahl, José M.   +2 more
core  

Some weighted operator geometric mean inequalities

Mathematical Researches, 2018
In this paper, using the extended Holder- -McCarthy inequality, several inequalities involving the α-weighted geometric mean ...
Alemeh Sheikhhosseini, Asma Ilkhanizadeh Manesh, Maryam Khosravi   +2 more
openaire   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

On generalized weighted means and compactness of matrix operators [PDF]

Annals of Functional Analysis, 2015
This paper mainly divided into two parts. The first part gives same facts about topological properties of certain linear topological spaces, inclusion relations and matrix mappings. The second part establishes some identities or estimates for the matrix operator norms and the Hausdorff measures of noncompactness of certain matrix operators ...
openaire   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source