Results 51 to 60 of about 402,705 (256)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Weighted extended mean values [PDF]
Colloquium Mathematicum, 2004 Summary: The author generalizes Stolarsky's Extended Mean Values to a four-parameter family of means \(F(r,s;a,b;x,y)=E(r,s;ax,by)/E(r,s;a,b)\) and investigates their monotonicity properties.
openaire +2 more sources
Feature Weighting in k-Means Clustering [PDF]
Machine Learning, 2003 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Modha, Dharmendra S., Spangler, W. Scott
openaire +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Optimal Power Mean Bounds for the Weighted Geometric Mean of Classical Means
Journal of Inequalities and Applications, 2010 For , the power mean of order of two positive numbers and is defined by , for , and , for . In this paper, we answer the question: what are the greatest value and the least value such that the double inequality holds for all and ...
Chu Yu-Ming, Long Bo-Yong
doaj +2 more sources
The Interval-Valued Intuitionistic Fuzzy Optimized Weighted Bonferroni Means and Their Application
Journal of Applied Mathematics, 2013 We investigate and propose two new Bonferroni means, that is, the optimized weighted BM (OWBM) and the generalized optimized weighted BM (GOWBM), whose characteristics are to reflect the preference and interrelationship of the aggregated arguments and ...
Ya-ming Shi, Jian-min He
doaj +1 more source
DIFFERENCE BETWEEN WEIGHTED INTEGRAL MEANS
Demonstratio Mathematica, 2002 Summary: Weighted integral means over \([c,d]\) and \([a,b]\) where \([c,d]\subset [a,b]\) are compared in the current work by determining bounds for their difference in terms of a variety of norms. The bounds are obtained and involve the behaviour of at most the first derivative.
openaire +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source