Results 91 to 100 of about 1,301,558 (327)
Doubly-weighted zero-sum constants
, 2023 20 ...
Paul, Krishnendu, Paul, Shameek
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Annals of GISLiving shoreline suitability assessments guide decisions on shoreline armoring, ensuring the most ecologically balanced shoreline protection methods are selected.
Afsheen Sadaf +2 more
doaj +1 more source
Weighted and restricted sum formulas of Euler sums
Research in Number TheoryOne of the most interesting formulas for multiple zeta values is the sum formula proved by Granville and Zagier independently in 1990s. Many variations and generalizations of it have been found since then. In this paper, we will provide a uniform approach to proving these results using the regularized double shuffle relations of Euler sums.
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Reduction of the sum of the weighted equal powers to explicit combinatorial representation
Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2012 The paper contains the proof of the statement that the component of the sum of weighted powers with natural bases and equal parameters, dependent on weight coefficients, is equal to the sum of products of binomial and weight coefficients.
Alexander I Nikonov
doaj
Weighted sum formula for multiple harmonic sums modulo primes
Proceedings of the American Mathematical Society, 2019 In this paper we prove a weighted sum formula for multiple harmonic sums modulo primes, thereby proving a weighted sum formula for finite multiple zeta values. Our proof utilizes difference equations for the generating series of multiple harmonic sums. We also conjecture several weighted sum formulas of similar flavor for finite multiple zeta values.
Hirose, Minoru +2 more
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Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source