Results 141 to 150 of about 211,923 (289)

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

open access: yesFEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru   +6 more
wiley   +1 more source

A conjecture of Schoenberg

open access: yesJournal of Inequalities and Applications, 1999
For an arbitrary polynomial with the sum of all zeros equal to zero, , the quadratic mean radius is defined by Schoenberg conjectured that the quadratic mean radii of and satisfy where equality holds if and only if the zeros all lie on a straight ...
Ivanov KG, Sharma A, de Bruin MG
doaj  

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

open access: yesFEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti   +3 more
wiley   +1 more source

Certain Polynomials with Weighted Sums

open access: yesJournal of the Chosun Natural Science, 2015
AbstractIn this note, we provide some examples of polynomials z n −p(z), where , and , a k ≥ 0 for eachk such that p(z) has all its zeros on |z|=c 1, and wedenote C(r) by the circle of radius r with center the ori-gin. It follows from Enestrm-Kakeya theorem [1] (see p.136 of [1] for the statement and its proof) to(1)where , a k ≥ 0 for each k that all
openaire   +2 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Sum and Weighted Sum Formulas for Fibonacci and Lucas Quaternions

open access: yesAksaray University Journal of Science and Engineering
Fibonacci and Lucas quaternions are deeply studied in the literature after its definition by Horadam in 1963. Binet formula, generation function, Cassini, Catalan, Honsberger, and other identities for these sequences studied in different quaternion algebra types like split quaternion algebra, dual quaternion algebra, etc.
openaire   +3 more sources

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

open access: yesFEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart   +7 more
wiley   +1 more source

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