Results 131 to 140 of about 1,216,959 (343)
Replication Regulates Volume Weighting in Quantum Cosmology
, 2009 Probabilities for observations in cosmology are conditioned both on the universe's quantum state and on local data specifying the observational situation.
Hartle, James, Hertog, Thomas
core +3 more sources
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Probability Weighting Functions* [PDF]
In this paper we begin by stressing the empirical importance of non-linear weighting of probabilities, which expected utility theory (EU) is unable to accommodate. We then go on to outline three stylized facts on non-linear weighting that any alternative
Ali al-Nowaihi, Sanjit Dhami
core
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Sample Weighting Methods for Compensating Class Imbalance in Elephant Flow Classification
IEEE AccessAccurately identifying and classifying elephant flows is crucial in many network traffic management applications. However, the inherent class imbalance between elephant and mouse flows presents a challenge for machine learning models, often leading to ...
Piotr Jurkiewicz +2 more
doaj +1 more source
Weak consistency of the 1-nearest neighbor measure with applications to missing data
, 2019 When data is partially missing at random, imputation and importance weighting are often used to estimate moments of the unobserved population. In this paper, we study 1-nearest neighbor (1NN) importance weighting, which estimates moments by replacing ...
Sharpnack, James
core
Comparing Entropy Weighting Method and AHP for JIT implementation in a Manufacturing System [PDF]
, 2015 Although some important criteria, such as work in process (WIP) and inventory, are recognized to have an impact on Just-in-Time (JIT) implementations, the exact weights of these criteria for different systems are not known.
Aghezzaf, El-Houssaine +2 more
core
T${}^2$K${}^2$: The Twitter Top-K Keywords Benchmark
, 2017 Information retrieval from textual data focuses on the construction of vocabularies that contain weighted term tuples. Such vocabularies can then be exploited by various text analysis algorithms to extract new knowledge, e.g., top-k keywords, top-k ...
A Guille +14 more
core +2 more sources
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source