Results 111 to 120 of about 451,044 (311)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Improving Standard Poststratification Techniques For Random-Digit-Dialing Telephone Surveys
Survey Research Methods, 2008 Random-digit-dialing surveys in the United States such as the Behavioral Risk Factor Surveillance System (BRFSS) typically poststratify on age, gender and race/ethnicity using control totals from an appropriate source such as the 2000 Census, the Current
Michael P. Battaglia +2 more
doaj +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
The effect of events between waves on panel attrition
Survey Research Methods, 2015 Panel surveys suffer from attrition. Most panel studies use propensity models or weighting class approaches to correct for non-random dropout. These models draw on variables measured in a previous wave or from paradata of the study. While it is plausible
Mark Trappmann +2 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Weighted (Co)homology and Weighted Laplacian
, 2018 In this paper, we generalize the combinatorial Laplace operator of Horak and Jost by introducing the $ϕ$-weighted coboundary operator induced by a weight function $ϕ$. Our weight function $ϕ$ is a generalization of Dawson's weighted boundary map.
Wu, Chengyuan +3 more
openaire +3 more sources
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Sample Weighting Methods for Compensating Class Imbalance in Elephant Flow Classification
IEEE AccessAccurately identifying and classifying elephant flows is crucial in many network traffic management applications. However, the inherent class imbalance between elephant and mouse flows presents a challenge for machine learning models, often leading to ...
Piotr Jurkiewicz +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source