Results 101 to 110 of about 25,035 (360)
Materials of the final reports on the joint Soviet-American experiment on the Kosmos-936 biosatellite [PDF]
Biological experiments onboard the Kosmos-936 investigated the effect of weightlessness on the basic components of cells, the genetic structure and energy apparatus. Genetic studies were made on the Drosophila melanogaster.
Dudkin, V. Y. +9 more
core +1 more source
Molecular Oncology, EarlyView.Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad +13 more
wiley +1 more source
Evaluation the effect of erythropoietin on osteoporosis in a microgravity simulation model [PDF]
فصلنامه ابن سینا, 2015 Background: Bone loss is a well-documented phenomenon occurring in humans both in short- and long-term spaceflights. Revealing data on the role of erythropoietin (EPO) in bone formation has led some to suggest that EPO treatment could also play a role in
A Khoshvaghti +2 more
doaj
Research opportunities in bone demineralization, phase 3 [PDF]
Bone demineralization, calcium responses to weightlessness, endocrine responses to weightlessness, mechanisms of bone loss, biomedical research, pathogenesis, and endocrine effects are ...
Anderson, S. A., Cohn, S. H.
core +2 more sources
Molecular Oncology, EarlyView.Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran +16 more
wiley +1 more source
Second All-Union Seminar on Hydromechanics and Heat and Mass Exchange in Weightlessness, summaries of reports [PDF]
s of reports are given which were presented at the Second All Union Seminar on Hydromechanics and Heat-Mass Transfer in Weightlessness. Topics include: (1) features of crystallization of semiconductor materials under conditions of microacceleration; (2 ...
Gershuni, G. Z., Zhukhovitskiy, Y. M.
core +1 more source
A note on $p$-adic simplicial volumes [PDF]
arXiv, 2020 We define and study generalizations of simplicial volume over arbitrary seminormed rings with a focus on $p$-adic simplicial volumes. We investigate the dependence on the prime and establish homology bounds in terms of $p$-adic simplicial volumes. As the main examples we compute the weightless and $p$-adic simplicial volumes of surfaces.
arxiv
Molecular Oncology, EarlyView.The authors conducted a retrospective study of 94 patients with advanced cancer who underwent next‐generation sequencing (NGS) gene panel analysis and received targeted treatments when applicable. Results further support evidence indicating that molecular profiling provides clinical benefit.
Michaël Dang +3 more
wiley +1 more source
Reactivity of organism in prolonged space flights [PDF]
An analysis of published data are presented as well as the results of experiments which show that the state of weightlessness and hypodynamia result in a reduced orthostatic and vestibular resistance, increased sensitivity to infections, decreased ...
Vasilyev, P. V.
core +1 more source
KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells
Molecular Oncology, EarlyView.We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock +10 more
wiley +1 more source