Results 111 to 120 of about 20,184 (348)
Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
Alterations in gut transport of minerals and in binding proteins during simulated weightlessness [PDF]
The structural components of the skeleton develop and are maintained in a 1 g environment, shaped by the mechanical load to which they are constantly exposed.
Bikle, D. D.
core +1 more source
Landscape of BRAF transcript variants in human cancer
Molecular Oncology, EarlyView.We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda +5 more
wiley +1 more source
Processing of Tomographic Data Using Weightless Neural Networks [PDF]
, 1997 A. York, P. M. Duggan
openalex +1 more source
Synergistic effect of zero-G and radiation on white blood cells. An experiment for the Gemini III manned space flight Annual report, period ending 30 Jun. 1965 [PDF]
Synergistic effect of weightlessness and radiation on white blood cells during Gemini 3 ...
Bender, M. A.
core +1 more source
Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren +16 more
wiley +1 more source
Editorial: Role of the vestibular system in the perception of time and space
Frontiers in Integrative Neuroscience, 2022 Pierre Denise +2 more
doaj +1 more source
Introduction to the physics of weightlessness [PDF]
Equations of motion for describing weightlessness phenomena during space ...
Orrok, G. T., Shapiro, S.
core +1 more source
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
A Systems Approach to the Physiology of Weightlessness [PDF]
A systems approach to the unraveling of the complex response pattern of the human subjected to weightlessness is presented. The major goal of this research is to obtain an understanding of the role that each of the major components of the human system ...
Leach, Carolyn S. +3 more
core +1 more source