Understanding and measuring mechanical signals in the tumor stroma
FEBS Open Bio, EarlyView.This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz +3 more
wiley +1 more source
Editorial: Rising stars in environmental, aviation and space physiology: 2022
Frontiers in Physiology, 2023 Alina Saveko +6 more
doaj +1 more source
Effects of weightlessness on the cardiovascular system: a systematic review and meta-analysis
Frontiers in PhysiologyBackground: The microgravity environment has a direct impact on the cardiovascular system due to the fluid shift and weightlessness that results in cardiac dysfunction, vascular remodeling, and altered Cardiovascular autonomic modulation (CAM ...
Rafaella Mendes Zambetta +7 more
doaj +1 more source
Synergistic effect of zero-G and radiation on white blood cells. An experiment for the Gemini III manned space flight Annual report, period ending 30 Jun. 1965 [PDF]
Synergistic effect of weightlessness and radiation on white blood cells during Gemini 3 ...
Bender, M. A.
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FEBS Open Bio, EarlyView.Novel mAbs could detect cancer‐associated membrane proteins on various type of pancreatic ductal adenocarcinomas (PDAC) by flow cytometry with viable PDAC cells and by immunohistochemistry with PDAC tissues. Results of protein expression were substantiated by mRNA expression by The Cancer Genome Atlas.
Takashi Nakano +16 more
wiley +1 more source
Multiple sclerosis clinical decision support system based on projection to reference datasets
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1863-1873, December 2022., 2022 Abstract Objective Multiple sclerosis (MS) is a multifactorial disease with increasingly complicated management. Our objective is to use on‐demand computational power to address the challenges of dynamically managing MS. Methods A phase 3 clinical trial data (NCT00906399) were used to contextualize the medication efficacy of peg‐interferon beta‐1a vs ...
Chadia Ed‐driouch +13 more
wiley +1 more source
Some observations during weightlessness sim- ulation with subject immersed in a rotating water tank [PDF]
Observations during weightlessness simulation with subject immersed in rotating water ...
Letko, W., Stone, R. W., Jr.
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HDAC4 regulates apoptosis in Acan‐CreERT2;HDAC4d/d mice with osteoarthritis by downregulating ATF4
FEBS Open Bio, EarlyView.Using the AcanCreERT2;HDAC4fl/fl genetic mouse model, we further investigated the role of histone deacetylase 4 (HDAC4) in chondrocyte apoptosis. We found that knocking down HDAC4 may be associated with chondrocyte apoptosis by upregulating the activating transcription factor 4 (ATF4)/CAAT/enhancer binding protein homologous (CHOP) signaling pathway ...
Jingrui Huang +11 more
wiley +1 more source
Clinical heterogeneity in a family with flail arm syndrome and review of hnRNPA1‐related spectrum
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1910-1917, December 2022., 2022 Abstract Objective Flail arm syndrome (FAS) is one of the atypical subtypes of amyotrophic lateral sclerosis (ALS). Mutations in hnRNPA1 encoding heterogeneous nuclear ribonucleoprotein (hnRNP) A1 are a rare genetic cause of ALS. Herein, marked clinical heterogeneity of FAS in a pedigree with a known hnRNPA1 variant was described to raise early ...
Xiaochen Han +5 more
wiley +1 more source
Vitamin D in Real and Simulated Weightlessness: Implications for Earth [PDF]
, 2006 Barbara Rice, Sara R. Zwart, S. M. Smith
openalex +1 more source