Results 201 to 210 of about 17,802 (285)

Man in Weightlessness

Journal of the Royal College of Physicians of London, 1969
openaire   +2 more sources

Gene Expression Profile of Gm20594 and Hapln1 in Mouse Cardiac Muscle Exposed to Microgravity and Space-like Chronic Low-Dose Radiation. [PDF]

MicroPubl Biol
Mackey E, Orr C, Jamshidi-Parsian A, Byrum S, Griffin R, Pathak R, Reyna NS.   +6 more
europepmc   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

The Heart in Space: Effects of Microgravity on Different Cell Types and Their Functions in the Cardiovascular System. [PDF]

Biomedicines
Shahzad Z, Rafay RH, Bala N, Dogan YE, Alli AA.   +4 more
europepmc   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

Ginsenoside Reshapes Intestinal Microecology to Alleviate Microgravity Stress. [PDF]

Drug Des Devel Ther
Wang Y, Chen T, Shi Z, Dong L, Li M, Peng B, Li Q, Pan R, Xiao S, Yang Q, Jiang N, Liu X, Hu Q, Chen Y.   +13 more
europepmc   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Microgravity Impacts the Expression of Aging-Associated Candidate Gene Targets in the p53 Regulatory Network. [PDF]

Int J Mol Sci
Kuznetsov NV, Vlasova DD, Kotikova AA, Tomilovskaya E, Ljubisavljevic M.   +4 more
europepmc   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Breath, Pulse, and Speech: A Multi-Parameter Wearable System using Airflow-Thermoelectric Fusion Technology. [PDF]

Adv Sci (Weinh)
Zhu Z, Yan X, Hou Y, Zeng Y, Li Z, Sun X, Li C, Liang X, Ding Q, Lei C, Wang Z.   +10 more
europepmc   +1 more source