Results 221 to 230 of about 25,035 (360)

Hydrophobicity causes anomalous migration of cystine/glutamate antiporter SLC7A11 in SDS‐PAGE with low acrylamide concentration

FEBS Open Bio, EarlyView.
SLC7A11 frequently migrates faster in SDS‐PAGE. The present study found that the high hydrophobicity of SLC7A11 causes its anomalous migration in SDS‐PAGE with a low concentration of acrylamide gel. Replacing isoleucine with asparagine reduced hydrophobicity and restored its normal migration at 55 kDa, revealing the role of hydrophobicity and gel ...
Nsengiyumva Emmanuel, Qian He, Yixin Kang, Dianbao Zhang, Min Gao, Minglin Wang, Kexin Fan, Jingwen Xiong, Shaobo Wu, Botao Fa, Zhengtao Xiao, Yingfang Niu, Jun Yao, Yilei Zhang   +13 more
wiley   +1 more source

Ground experiments for finding principles and working out methods for preventing adverse effects of weightlessness on the human organism [PDF]

A comparative assessment of the effectiveness of different prophylactic procedures to prevent the adverse effects of weightlessness is presented. It is concluded that: physical training is most effective but no single method by itself produces the full ...
Gregoryev, A. I., Kakurin, L. I., Mikhailov, V. M., Tishler, V. A.   +3 more
core   +1 more source

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

Wetting film dynamics during evaporation under weightlessness in a near-critical fluid

, 2005
John Hegseth, Ana Oprisan, Yves Garrabos, Vadim S. Nikolayev, Carole Lecoutre-Chabot, D. Beysens   +5 more
openalex   +2 more sources

From a Weightless Bent Wire Coat Hanger to Shell Structures Via the Beltrami Stress Tensor [PDF]

, 2017
Samar Malek, Allan McRobie, Paul Shepherd, Christopher Williams   +3 more
openalex   +1 more source

Study of physiological tolerance to centrifugation Final report [PDF]

Physiological effects and acceleration tolerances after weightlessness based on space environment simulation with human centrifuges and bed ...
Benedict, J. V., Miller, D. M., Nickel, J. A., Ward, B.   +3 more
core   +1 more source

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

FEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei, Zhanbiao Liu, Jingjing Shi, Qian Jin, Wenqian Chen, Xuejun Chen, Liqin Li, Hui Chen   +7 more
wiley   +1 more source

Microbiota–Muscle/–Immune Interactions in Rhesus Macaque under Simulated Weightlessness Revealed by Integrated Multi-Omics Analysis

, 2021
Peng Zhang, Libin Shao, Jie Zhang, Lu Wang, Huimei Yuan, Xiangsheng Pang, Guangyi Fan, Ling Peng, Guanghan Kan, Wenjiong Li, Xinming Liang, Xin Liu, Xiaoping Chen   +12 more
openalex   +1 more source

Simulated weightlessness in fish and neurophysiological studies on memory storage [PDF]

Simulated weightlessness was used to study the different types of gravity responses in blind fish. It was found that a shift in the direction of low magnitude acceleration in weightlessness causes a rapid 180 deg turn in the blind fish, while a shift in ...
Vonbaumgarten, R. J.
core   +1 more source

Advanced glycation end products promote the release of endothelial cell‐derived mitocytosis

FEBS Open Bio, EarlyView.
Under diabetic conditions, AGEs induce mitochondrial damage in HUVECs, activating migrasome‐mediated mitocytosis. Migrasomes encapsulate damaged mitochondria and are released into the extracellular space, facilitating intercellular mitochondrial transfer.
Rong Liu, Yuhao Zhang, Tiantian Ge, Hao Wu, Yongbin Ma, Honghua Ye, Fei Guo   +6 more
wiley   +1 more source