Results 41 to 50 of about 6,366 (302)
Joint Cartilage in Long-Duration Spaceflight
Biomedicines, 2022 This review summarizes the current literature available on joint cartilage alterations in long-duration spaceflight. Evidence from spaceflight participants is currently limited to serum biomarker data in only a few astronauts.
Bergita Ganse +2 more
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Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Frontiers in Physiology, 2020 BackgroundProfound knowledge about cardiovascular physiology in the setting of microgravity can help in the course of preparations for human space missions.
Nana-Yaw Bimpong-Buta +8 more
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FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
The Mechanoreception in Drosophila melanogaster Oocyte under Modeling Micro- and Hypergravity
Cells, 2023 The hypothesis about the role of the cortical cytoskeleton as the primary mechanosensor was tested. Drosophila melanogaster oocytes were exposed to simulated microgravity (by 3D clinorotation in random directions with 4 rotations per minute—sµg group ...
Irina V. Ogneva
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Cardiovascular Adaptation to Weightlessness
SAE Technical Paper Series, 1982 <div class="htmlview paragraph">Exposure to actual and simulated zero gravity causes a significant central or cephalad shift of intravascular and interstitial fluid which triggers a complex set of cardiovascular and systemic adaptations. These adaptations are, in turn, directly responsible for the cardiovascular dysfunction that is apparent after
openaire +3 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Авіаційно-космічна техніка та технологія, 2021 Spacecraft thermal control systems based on two-phase mechanically pumped loops have advantages in terms of mass and power consumption for auxiliary needs compared to single-phase thermal control systems.
Artem Hodunov +2 more
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FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Molecular Brain, 2019 The microgravity environment in space can impact astronauts’ cognitive and behavioral activities. However, due to the limitations of research conditions, studies of biological changes in the primate brain, such as neurogenesis, have been comparatively ...
Xu Zhang +10 more
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